Role of untranslated regions in mRNA translation and stability

被引：0
作者：
Diederich, M
Kruys, V
Wellman, M
机构：
来源：
M S-MEDECINE SCIENCES | 1997年 / 13卷 / 11期
关键词：
D O I：
10.4267/10608/545
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The biochemical life of mRNA migrating from the nucleus to the cytoplasm is controled by numerous interactions with regulatory proteins. Most of those steps are under the control of the 5' and 3' untranslated regions interacting with specific regulatory proteins and directing transport, translation and stabilization of the mRNA. Similar to DNA, mRNA carry cis-acting sequences allowing the cell to respond to numerous endogenous trans-acting factors able to adapt translation of the message to different physiopathological situations. These regulatory elements could be compared to promoting and enhancing transcriptional sequences. The remaining question is: do mRNA really have promoters?
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页码：1266 / 1276
页数：11
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