The twilight of the immune system: The impact of immunosenescence in aging

被引：49

作者：

Feehan, Jack ^{[1
,2
,3
,4
]}

Tripodi, Nicholas ^{[1
,3
,4
]}

Apostolopoulos, Vasso ^{[1
]}

机构：

[1] Victoria Univ, Inst Hlth & Sport, Melbourne, Vic, Australia

[2] Univ Melbourne, Dept Med, Western Hlth, Melbourne, Vic, Australia

[3] Univ Melbourne, Victoria Univ, Australian Inst Musculoskeletal Sci, Melbourne, Vic, Australia

[4] Western Hlth, Melbourne, Vic, Australia

来源：

MATURITAS | 2021年 / 147卷

关键词：

Senescence; Geroscience; Immunosenescence; Inflammaging; Aging; SECRETORY PHENOTYPE; T-CELLS; CELLULAR SENESCENCE; LUNG-CANCER; ROLES; CONSEQUENCES; ACCUMULATION; VACCINATION; EXHAUSTION;

D O I：

10.1016/j.maturitas.2021.02.006

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Cellular senescence is a critical part of human anti-tumor defence; however, the accumulation of senescent cells with age underpins a wide range of pathologies. Senescent change in immune cells, or immunosenescence, has a wide range of physiological effects and is at least partially responsible for many diseases associated with aging. Immunosenescence underpins inflammaging, increased vulnerability to infectious disease with age, malignant change in the elderly, and auto-immunity. Understanding the effects and mechanisms of immunosenescence will improve disease outcomes and prevention in older adults, and generate new treatments for common illnesses. In this review we summarize the key changes occurring in immunosenescence across each facet of the immune system, and identify their clinical correlates.

引用

页码：7 / 13

页数：7

共 63 条

[1]

Agrawal A, 2012, EXPERT REV CLIN IMMU, V8, P73, DOI [10.1586/eci.11.77, 10.1586/ECI.11.77]

[2] Senescence of T Lymphocytes: Implications for Enhancing Human Immunity [J].

Akbar, Arne N. ;

Henson, Sian M. ;

Lanna, Alessio .

TRENDS IN IMMUNOLOGY, 2016, 37 (12) :866-876

[3] Senescent cells: Living or dying is a matter of NK cells [J].

Antonangeli, Fabrizio ;

Zingoni, Alessandra ;

Soriani, Alessandra ;

Santoni, Angela .

JOURNAL OF LEUKOCYTE BIOLOGY, 2019, 105 (06) :1275-1283

[4] Immunosenescence: emerging challenges for an ageing population [J].

Aw, Danielle ;

Silva, Alberto B. ;

Palmer, Donald B. .

IMMUNOLOGY, 2007, 120 (04) :435-446

[5] Naturally occurring p16Ink4a-positive cells shorten healthy lifespan [J].

Baker, Darren J. ;

Childs, Bennett G. ;

Durik, Matej ;

Wijers, Melinde E. ;

Sieben, Cynthia J. ;

Zhong, Jian ;

Saltness, Rachel A. ;

Jeganathan, Karthik B. ;

Verzosa, Grace Casaclang ;

Pezeshki, Abdulmohammad ;

Khazaie, Khashayarsha ;

Miller, Jordan D. ;

van Deursen, Jan M. .

NATURE, 2016, 530 (7589) :184-+

[6] The influence and impact of ageing and immunosenescence (ISC) on adaptive immunity during multiple sclerosis (MS) and the animal counterpart experimental autoimmune encephalomyelitis (EAE) [J].

Bolton, Christopher ;

Smith, Paul A. .

AGEING RESEARCH REVIEWS, 2018, 41 :64-81

[7]

Butcher SK, 2001, J LEUKOCYTE BIOL, V70, P881

[8]

Chandra T, 2016, FUNCTIONAL NUCLEUS, P205, DOI 10.1007/978-3-319-38882-3_9

[9] Global Reorganization of the Nuclear Landscape in Senescent Cells [J].

Chandra, Tamir ;

Ewels, Philip Andrew ;

Schoenfelder, Stefan ;

Furlan-Magaril, Mayra ;

Wingett, Steven William ;

Kirschner, Kristina ;

Thuret, Jean-Yves ;

Andrews, Simon ;

Fraser, Peter ;

Reik, Wolf .

CELL REPORTS, 2015, 10 (04) :471-483

[10]

Chou JP, 2013, CURR PHARM DESIGN, V19, P1680

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