Tuning bio-aerogel properties for controlling theophylline delivery. Part 1: Pectin aerogels

被引：32

作者：

Groult, Sophie ^{[1
]}

Buwalda, Sytze ^{[1
]}

Budtova, Tatiana ^{[1
]}

机构：

[1] PSL Res Univ, UMR CNRS 7635, Ctr Mat Forming CEMEF, MINES ParisTech, CS 10207, F-06904 Sophia Antipolis, France

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2021年 / 126卷

关键词：

Pectin; Aerogel; Drug release; Theophylline; Kinetics; Specific surface area; CONTROLLED DRUG-DELIVERY; RELEASE; MECHANISMS; ADSORPTION; GELATION;

D O I：

10.1016/j.msec.2021.112148

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A comprehensive study of release kinetics of a hydrophilic drug from bio-aerogels based on pectin was performed. Pectin aerogels were made by polymer dissolution, gelation (in some cases this step was omitted), solvent exchange and drying with supercritical CO2. Theophylline was loaded and its release was studied in the simulated gastric fluid during 1 h followed by the release in the simulated intestinal fluid. Pectin concentration, initial solution pH and concentration of calcium were varied to tune the properties of aerogel. The kinetics of theophylline release was monitored and correlated with aerogel density, specific surface area, and aerogel swelling and erosion. Various kinetic models were tested to identify the main physical mechanisms governing the release.

引用

页数：11

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