Stereocontrolled synthesis of dafachronic acid A, the ligand for the DAF-12 nuclear receptor of Caenorhabditis elegans

被引：34

作者：

Giroux, Simon ^{[1
]}

Corey, E. J. ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 32期

关键词：

D O I：

10.1021/ja074306i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient synthetic route to the DAF-12 nuclear receptor ligand of C. elegans, dafachronic acid, is described that starts with the abundant plant sterol beta-stigmasterol and proceeds in 37% overall yield. The synthesis establishes the structure of this rare nematode hormone.

引用

页码：9866 / +

页数：3

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