Cross-Reactivity Between Molds and Mushrooms

Fungi are considered one of the most common allergens responsible for type I allergies. This allergic response can be triggered by inhalation of mold spores, skin contact, or ingestion of mushrooms. There are some case reports in the literature advocating an association between sensitization to mold spores and systemic reactions caused by ingestion of mushrooms. However, this association is scarce and not completely explored. The authors report a case of a 12-year-old girl, with symptoms compatible with allergic rhinitis not previously studied, who developed an anaphylatic reaction after ingestion of mushrooms (Macrolepiota procera). The skin prick test revealed sensitivity to Cladosporium herbarum and the prick-to-prick test with the Parasol mushroom (M. procera) was positive, which highlighted the possibility of cross-reactivity between molds and mushrooms, hypothesis that was suggested by Western blot and inhibition test.