Elevated erythropoietin in vitreous with ischemic retinal diseases

被引：63

作者：

Inomata, Y ^{[1
]}

Hirata, A ^{[1
]}

Takahashi, E ^{[1
]}

Kawaji, T ^{[1
]}

Fukushima, M ^{[1
]}

Tanihara, H ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Med Sci, Dept Ophthalmol & Visual Sci, Kumamoto 8608556, Japan

来源：

NEUROREPORT | 2004年 / 15卷 / 05期

关键词：

erythropoietin; neuroprotection; vascular endothelial growth factor;

D O I：

10.1097/00001756-200404090-00029

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of the current study was to measure the concentrations of erythropoietin in the vitreous fluid and analyze its association with vascular endothelial growth factor (VEGF) in ischemic vitreoretinal diseases. Vitreous fluid samples were collected from patients with proliferative diabetic retinopathy, branch retinal vein occlusion and idiopathic macular hole. Concentrations of erythropoietin and VEGF in vitreous fluid were significantly elevated in patients with proliferative diabetic retinopathy and branch retinal vein occlusion as compared to patients with macular hole. There were no differences in serum concentrations of erythropoietin and VEGF among patient groups. There was significant correlation between erythropoietin and VEGF concentrations in vitreous fluid. Erythropoietin was up-regulated in ischemic disorders and may act as an endogenous neuroprotective factor against ischemic retinal disorders.

引用

页码：877 / 879

页数：3

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