MicroRNA-140 and the silencing of osteoarthritis

被引：58

作者：

Araldi, Elisa ^{[1
]}

Schipani, Ernestina ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Endocrine Unit, Boston, MA 02114 USA

来源：

GENES & DEVELOPMENT | 2010年 / 24卷 / 11期

关键词：

MicroRNA; miR-140; osteoarthritis; cartilage; Adamts-5; JOINT FORMATION; SMALL RNAS; CARTILAGE; MATRIX; DICER; MORPHOGENESIS; DIFFERENTIATION; PROLIFERATION; DEGRADATION; BIOGENESIS;

D O I：

10.1101/gad.1939310

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs (miRNAs) have emerged as important modulators in development, tissue homeostasis, and diseases. In this issue of Genes & Development, Miyaki and colleagues (pp. 1173-1185) report that miR-140 is involved in the pathogenesis of osteoarthritis by regulating, at least in part, ADAMTS5. Moreover, mice lacking miR-140 are dwarf as a consequence of impaired chondrocyte proliferation. This study is the first in vivo demonstration that miR-140 has a critical and nonredundant role in cartilage development and homeostasis.

引用

页码：1075 / 1080

页数：6

共 49 条

[1] MicroRNA-27b Regulates the Expression of Matrix Metalloproteinase 13 in Human Osteoarthritis Chondrocytes [J].

Akhtar, Nahid ;

Rasheed, Zafar ;

Ramamurthy, Sangeetha ;

Anbazhagan, Arivarasu N. ;

Voss, Frank R. ;

Haqqi, Tariq M. .

ARTHRITIS AND RHEUMATISM, 2010, 62 (05) :1361-1371

[2] Animal models of osteoarthritis: lessons learned while seeking the 'Holy Grail' [J].

Ameye, Laurent G. ;

Young, Marian F. .

CURRENT OPINION IN RHEUMATOLOGY, 2006, 18 (05) :537-547

[3] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[4] Hyaluronan synthesis and degradation in cartilage and bone [J].

Bastow, E. R. ;

Byers, S. ;

Golub, S. B. ;

Clarkin, C. E. ;

Pitsillides, A. A. ;

Fosang, A. J. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2008, 65 (03) :395-413

[5] Dicer is essential for mouse development [J].

Bernstein, E ;

Kim, SY ;

Carmell, MA ;

Murchison, EP ;

Alcorn, H ;

Li, MZ ;

Mills, AA ;

Elledge, SJ ;

Anderson, KV ;

Hannon, GJ .

NATURE GENETICS, 2003, 35 (03) :215-217

[6] The microRNA.org resource: targets and expression [J].

Betel, Doron ;

Wilson, Manda ;

Gabow, Aaron ;

Marks, Debora S. ;

Sander, Chris .

NUCLEIC ACIDS RESEARCH, 2008, 36 :D149-D153

[7] Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton [J].

Brunet, LJ ;

McMahon, JA ;

McMahon, AP ;

Harland, RM .

SCIENCE, 1998, 280 (5368) :1455-1457

[8] The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation [J].

Chen, JF ;

Mandel, EM ;

Thomson, JM ;

Wu, QL ;

Callis, TE ;

Hammond, SM ;

Conlon, FL ;

Wang, DZ .

NATURE GENETICS, 2006, 38 (02) :228-233

[9] Ancient animal microRNAs and the evolution of tissue identity [J].

Christodoulou, Foteini ;

Raible, Florian ;

Tomer, Raju ;

Simakov, Oleg ;

Trachana, Kalliopi ;

Klaus, Sebastian ;

Snyman, Heidi ;

Hannon, Gregory J. ;

Bork, Peer ;

Arendt, Detlev .

NATURE, 2010, 463 (7284) :1084-U105

[10] Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage [J].

Dy, Peter ;

Smits, Patrick ;

Silvester, Amber ;

Penzo-Mendez, Alfredo ;

Dumitriu, Bogdan ;

Han, Yu ;

de la Motte, Carol A. ;

Kingsley, David M. ;

Lefebvre, Veronique .

DEVELOPMENTAL BIOLOGY, 2010, 341 (02) :346-359

← 1 2 3 4 5 →