Specific self-antigen-driven immune response in pericardial effusion as an isolated GVHD manifestation

被引：8

作者：

Lev, A. ^{[1
,2
]}

Amariglio, N. ^{[1
,2
,3
]}

Spirer, Z. ^{[2
,4
]}

Katz, U. ^{[2
,5
]}

Bielorai, B. ^{[2
,6
]}

Rechavi, G. ^{[1
,2
]}

Somech, R. ^{[1
,2
,4
]}

机构：

[1] Chaim Sheba Med Ctr, Canc Res Ctr, IL-52621 Tel Hashomer, Israel

[2] Sackler Sch Med, Tel Aviv, Israel

[3] Chaim Sheba Med Ctr, Hematol Lab, IL-52621 Tel Hashomer, Israel

[4] Safra Childrens Hosp, Chaim Sheba Med Ctr, Pediat Immunol Serv, Tel Hashomer, Israel

[5] Safra Childrens Hosp, Chaim Sheba Med Ctr, E Safra Congenital Heart Dis Ctr, Pediat Cardiol Clin, Tel Hashomer, Israel

[6] Safra Childrens Hosp, Chaim Sheba Med Ctr, Bone Marrow Transplantat Unit, Pediat Hematol Oncol Div, Tel Hashomer, Israel

来源：

BONE MARROW TRANSPLANTATION | 2010年 / 45卷 / 06期

关键词：

GVHD; pericardial effusion; tamponade; thymus; TCR; VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; CARDIAC-TAMPONADE; IMMUNODEFICIENCY; PATIENT;

D O I：

10.1038/bmt.2009.314

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Pericardial effusion and cardiac tamponade have been described as GVHD manifestations in the post transplant period. Direct evidence of GVHD-related TCR or B-cell receptor clones in patients with pericardial effusion has never been described. Using several methods, including FACS and spectratyping analysis to assess T- and B-cell clonality and to quantify TCR excision circles to assess newly thymus-derived T cells, we were able to show expansion of oligoclonal T-cell populations and the possible presence of early/premature B cells in the pericardial effusion but not in peripheral mononuclear cells. This may explain the presentation of an isolated GVHD manifestation. Bone Marrow Transplantation (2010) 45, 1084-1087; doi:10.1038/bmt.2009.314; published online 16 November 2009

引用

页码：1084 / 1087

页数：4

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