5-Aryl-2-furaldehydes in the synthesis of tetrahydropyrimidinones by Biginelli reaction

被引：7

作者：

Vakhula, Andriy R. ^{[1
]}

Horak, Yuriy I. ^{[1
]}

Lytvyn, Roman Z. ^{[1
]}

Lesyuk, Alexandra I. ^{[1
]}

Kinzhybalo, Vasyl ^{[2
]}

Zubkov, Fedor I. ^{[3
]}

Obushak, Mykola D. ^{[1
]}

机构：

[1] Ivan Franko Natl Univ Lviv, 6 Kyryla & Mefodiya St, UA-79005 Lvov, Ukraine

[2] Inst Low Temperatures & Struct Res, PL-50422 Wroclaw, Poland

[3] RUDN Univ, 6 Miklukho Maklaya St, Moscow 117198, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2018年 / 54卷 / 05期

关键词：

5-aryl-2-furaldehydes; pyrimidine derivatives; tetrahydropyrimidines; Biginelli reaction; crystal structure; multicomponent reactions; DIVERSITY-ORIENTED SYNTHESIS; CALCIUM-CHANNEL BLOCKERS; MULTICOMPONENT REACTIONS; X-RAY; ANTIHYPERTENSIVE AGENTS; ARYLATION PRODUCTS; ACID-ESTERS; CHEMISTRY; HETEROCYCLES; DERIVATIVES;

D O I：

10.1007/s10593-018-2301-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Aryl-2-furaldehydes, obtained by furfural arylation with arenediazonium salts, react with ethyl acetoacetate or acetylacetone and (thio)-urea in the presence of FeCl3 center dot 6H(2)O as a catalyst. A series of ethyl 4-(5-aryl-2-furyl)-6-methyl-2-oxo(thioxo)-1,2,3,4-tetrahydropyrimidine-5-carboxylates was obtained.

引用

页码：545 / 549

页数：5

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