Mini Review: Bacterial Membrane Composition and Its Modulation in Response to Stress

被引：81

作者：

Willdigg, Jessica R. ^{[1
]}

Helmann, John D. ^{[1
]}

机构：

[1] Cornell Univ, Dept Microbiol, Ithaca, NY 14850 USA

来源：

FRONTIERS IN MOLECULAR BIOSCIENCES | 2021年 / 8卷

基金：

美国国家卫生研究院;

关键词：

bacteria; membrane; lipid; cellular envelope; antimicrobial resistance; metabolism; Bacillus subtilis; BACILLUS-SUBTILIS SIGMA(W); 2-COMPONENT REGULATORY SYSTEM; CELL-ENVELOPE; ANTIMICROBIAL PEPTIDES; INTRAMEMBRANE PROTEOLYSIS; BACITRACIN RESISTANCE; INTRINSIC RESISTANCE; ACID SYNTHESIS; PROTEIN; IDENTIFICATION;

D O I：

10.3389/fmolb.2021.634438

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antibiotics and other agents that perturb the synthesis or integrity of the bacterial cell envelope trigger compensatory stress responses. Focusing on Bacillus subtilis as a model system, this mini-review summarizes current views of membrane structure and insights into how cell envelope stress responses remodel and protect the membrane. Altering the composition and properties of the membrane and its associated proteome can protect cells against detergents, antimicrobial peptides, and pore-forming compounds while also, indirectly, contributing to resistance against compounds that affect cell wall synthesis. Many of these regulatory responses are broadly conserved, even where the details of regulation may differ, and can be important in the emergence of antibiotic resistance in clinical settings.

引用

页数：11

共 145 条

[1] Signal Sensing and Transduction by Histidine Kinases as Unveiled through Studies on a Temperature Sensor [J].

Abriata, Luciano A. ;

Albanesi, Daniela ;

Dal Peraro, Matteo ;

de Mendoza, Diego .

ACCOUNTS OF CHEMICAL RESEARCH, 2017, 50 (06) :1359-1366

[2] Structural Basis for Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus aureus [J].

Albanesi, Daniela ;

Reh, Georgina ;

Guerin, Marcelo E. ;

Schaeffer, Francis ;

Debarbouille, Michel ;

Buschiazzo, Alejandro ;

Schujman, Gustavo E. ;

de Mendoza, Diego ;

Alzari, Pedro M. .

PLOS PATHOGENS, 2013, 9 (01)

[3] The Bacillus subtilis acyl lipid desaturase is a Δ5 desaturase [J].

Altabe, SG ;

Aguilar, P ;

Caballero, GM ;

de Mendoza, D .

JOURNAL OF BACTERIOLOGY, 2003, 185 (10) :3228-3231

[4] Flotillins functionally organize the bacterial membrane [J].

Bach, Juri Nino ;

Bramkamp, Marc .

MOLECULAR MICROBIOLOGY, 2013, 88 (06) :1205-1217

[5] Hopanoid lipids: from membranes to plant-bacteria interactions [J].

Belin, Brittany J. ;

Busset, Nicolas ;

Giraud, Eric ;

Molinaro, Antonio ;

Silipo, Alba ;

Newman, Dianne K. .

NATURE REVIEWS MICROBIOLOGY, 2018, 16 (05) :304-315

[6] Now Playing: Farnesol in the Biofilm [J].

Bell, Stephen A. ;

Chappell, Joseph .

CHEMISTRY & BIOLOGY, 2014, 21 (11) :1421-1422

[7]

Benjdia A, 2017, NAT CHEM, V9, P698, DOI [10.1038/NCHEM.2714, 10.1038/nchem.2714]

[8] Metabolic control of the membrane fluidity in Bacillus subtilis during cold adaptation [J].

Beranova, Jana ;

Jemiola-Rzeminska, Malgorzata ;

Elhottova, Dana ;

Strzalka, Kazimierz ;

Konopasek, Ivo .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2008, 1778 (02) :445-453

[9] Functional association of the stress-responsive LiaH protein and the minimal TatAyCy protein translocase in Bacillus subtilis [J].

Bernal-Cabas, Margarita ;

Miethke, Marcus ;

Antelo-Varela, Minia ;

Suarez, Rocio Aguilar ;

Neef, Jolanda ;

Schon, Larissa ;

Gabarrini, Giorgio ;

Otto, Andreas ;

Becher, Doerte ;

Wolf, Diana ;

van Dijl, Jan Maarten .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2020, 1867 (08)

[10] A polycyclic terpenoid that alleviates oxidative stress [J].

Bosak, T. ;

Losick, R. M. ;

Pearson, A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (18) :6725-6729

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