DPPH Scavenging Assay of Novel 1,3-disubstituted-1H-pyrazol-5-ols and their in silico Studies on Some Proteins Involved in Alzheimer's Disease Signaling Cascade

被引：36
作者：
Sarojini, Balladka Kunhanna [1 ]
Vidyagayatri, Marakkur [1 ,2 ]
Darshanraj, Chenna Govindaraju [1 ]
Bharath, Basavapattana Rudresh [3 ]
Manjunatha, Hanumanthappa [3 ]
机构：
[1] PA Coll Engn, Dept Chem, Mangalore 574153, Karnataka, India
[2] Syngine Int Ltd, SUO13, Bangalore 99, Karnataka, India
[3] Kuvempu Univ, Dept PG Studies & Res Biotechnol & Bioinformat, Shankaraghatta 577451, Karnataka, India
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2010年 / 7卷 / 03期
关键词：
AD; Pyrazole derivative; DPPH assay; Molecular docking studies; GSK-3; beta; beta-secretase; INHIBITION;
D O I：
10.2174/157018010790596588
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of new 1,3-disubstituted-1H-pyrazol-5-ols (3) which are the analogues of known radical scavenger 'edaravone' are synthesized, characterized and evaluated for DPPH scavenging capacity. The docking studies are carried out for these compounds in the enol form and also in the respective keto form against the proteins and peptides involved in Alzhemier disease signal cascade. Some of them showed good radical scavenging capacity and molecular binding.
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页码：214 / 224
页数：11
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