Microbial Metabolism. Part 11. Metabolites of Flutamide

被引：9
|
作者：
Herath, Wimal [1 ]
Khan, Ikhlas Ahmad [1 ,2 ]
机构：
[1] Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA
[2] Univ Mississippi, Pharmaceut Sci Res Inst, Dept Pharmacognosy, Sch Pharm, University, MS 38677 USA
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 04期
基金：
美国农业部;
关键词：
flutamide; microbial metabolism; Rhodotorula mucilaginosa; HUMAN LIVER-MICROSOMES; INDUCED HEPATIC-DYSFUNCTION; PROSTATE-CANCER; IN-VITRO; BIOACTIVATION; IDENTIFICATION; TRANSFORMATION; URINE;
D O I：
10.1248/cpb.58.562
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The yeast culture, Rhodotorula mucilaginosa (ATCC 20129) transformed flutamide (1) to three metabolites: 4-nitro-3-(tritluoromethyl)aniline (2), 2-methyl-N-[4-amino-3-(trifloromethyl)phenyl]propanamide (3) and N-[4-amino-3-(trifluoromethyl)phenyl]acetamide (4). The structures were established by spectroscopic methods.
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页码：562 / 564
页数：3
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