Microbial Metabolism. Part 11. Metabolites of Flutamide

被引：9
|
作者：
Herath, Wimal [1 ]
Khan, Ikhlas Ahmad [1 ,2 ]
机构：
[1] Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA
[2] Univ Mississippi, Pharmaceut Sci Res Inst, Dept Pharmacognosy, Sch Pharm, University, MS 38677 USA
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 04期
基金：
美国农业部;
关键词：
flutamide; microbial metabolism; Rhodotorula mucilaginosa; HUMAN LIVER-MICROSOMES; INDUCED HEPATIC-DYSFUNCTION; PROSTATE-CANCER; IN-VITRO; BIOACTIVATION; IDENTIFICATION; TRANSFORMATION; URINE;
D O I：
10.1248/cpb.58.562
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The yeast culture, Rhodotorula mucilaginosa (ATCC 20129) transformed flutamide (1) to three metabolites: 4-nitro-3-(tritluoromethyl)aniline (2), 2-methyl-N-[4-amino-3-(trifloromethyl)phenyl]propanamide (3) and N-[4-amino-3-(trifluoromethyl)phenyl]acetamide (4). The structures were established by spectroscopic methods.
引用
收藏
页码：562 / 564
页数：3
相关论文
共 50 条
  • [1] Microbial metabolism. Part 13.1 Metabolites of hesperetin
    Herath, Wimal
    Khan, Ikhlas Ahmad
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (19) : 5784 - 5786
  • [2] Microbial metabolism. Part 14. Isolation and bioactivity evaluation of microbial metabolites of resveratrol
    Herath, Wimal
    Khan, Shabana Iqrar
    Khan, Ikhlas Ahmad
    NATURAL PRODUCT RESEARCH, 2013, 27 (16) : 1437 - 1444
  • [3] Microbial metabolism. Part 7: Curcumin
    Herath, Wimal
    Ferreira, Daneel
    Khan, Ikhlas A.
    NATURAL PRODUCT RESEARCH, 2007, 21 (05) : 444 - 450
  • [4] Microbial metabolism. Part 6. Metabolites of 3- and 7-hydroxyflavones
    Herath, W
    Mikell, JR
    Hale, AL
    Ferreira, D
    Khan, IA
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2006, 54 (03) : 320 - 324
  • [5] Microbial metabolism. Part 5. Dihydrokawain
    Herath, W
    Ferreira, D
    Mikell, JR
    Khan, IA
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2004, 52 (11) : 1372 - 1374
  • [6] Microbial Metabolism. Part 12. Isolation, Characterization and Bioactivity Evaluation of Eighteen Microbial Metabolites of 4′-Hydroxyflavanone
    Mikell, Julie Rakel
    Herath, Wimal
    Khan, Ikhlas Ahmad
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2011, 59 (06) : 692 - 697
  • [7] Microbial metabolism. Part 10: Metabolites of 7,8-dimethoxyflavone and 5-methoxyflavone
    Herath, Wimal
    Mikell, Julie Rakel
    Khan, Ikhlas Ahmad
    NATURAL PRODUCT RESEARCH, 2009, 23 (13) : 1231 - 1239
  • [8] Microbial metabolism. Part 8. The pyranocoumarin, decursin
    Herath, Witnal
    Reddy, Niranjan
    Khan, Ikhlas Ahmad
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2007, 55 (10) : 1512 - 1513
  • [9] Part 11. Viewpointing
    Dubord, Greg
    CANADIAN FAMILY PHYSICIAN, 2011, 57 (10) : 1163 - 1163
  • [10] The part played by the liver in purine metabolism.
    Paroulek
    ACTA MEDICA SCANDINAVICA, 1928, 68 (01): : 79 - 95
12345