FGF23-Associated Tumor-Induced Osteomalacia in a Patient With Small Cell Carcinoma: A Case Report and Regulatory Mechanism Study

被引：21

作者：

Sauder, Adrienne ^{[1
]}

Wiernek, Szymon ^{[2
]}

Dai, Xumin ^{[2
]}

Pereira, Renata ^{[3
]}

Yudd, Michael ^{[4
]}

Patel, Charvi ^{[1
]}

Golden, Andrew ^{[1
]}

Ahmed, Shahida ^{[4
]}

Choe, Jin ^{[4
]}

Chang, Victor ^{[4
]}

Sender, Slawomir ^{[4
]}

Cai, Donghong ^{[4
]}

机构：

[1] Rutgers New Jersey Med Sch, Newark, NJ USA

[2] Univ N Carolina, Chapel Hill, NC USA

[3] Univ Calif Los Angeles, Los Angeles, CA USA

[4] VA New Jersey Med Ctr, E Orange, NJ USA

来源：

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2016年 / 24卷 / 02期

关键词：

small cell carcinoma; tumor-induced osteomalacia; FGF23; wnt signaling pathway; OF-THE-LITERATURE; ONCOGENIC OSTEOMALACIA; MESENCHYMAL TUMORS; PHOSPHATE; CANCER; HYPOPHOSPHATEMIA; LIVER; FGF23;

D O I：

10.1177/1066896915617828

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Tumor-induced osteomalacia (TIO) is typically caused by phosphaturic mesenchymal tumor (PMT) that secretes the phosphaturic hormone, fibroblast growth factor-23 (FGF23), resulting in decreased phosphate reabsorption in kidneys, hypophosphatemia, and finally osteomalacia. Rare cases of malignant tumor manifesting with TIO other than PMT had been reported, although in most of these reports, except one, circulating FGF23 levels were not evaluated and tissue expressing of FGF23 was not confirmed. In this article, we report a case of TIO in a patient with pulmonary small cell carcinoma with liver metastasis. The patient manifested with hypophosphatemia. His circulating level of FGF23 was markedly increased. The expression of FGF23 in tumor cells was confirmed. Furthermore, the regulatory mechanism of FGF23 in this patient was also investigated.

引用

收藏

页码：116 / 120

页数：5

相关论文

共 19 条

[1] RT-PCR Analysis for FGF23 Using Paraffin Sections in the Diagnosis of Phosphaturic Mesenchymal Tumors With and Without Known Tumor Induced Osteomalacia [J].

Bahrami, Armita ;

Weiss, Sharon W. ;

Montgomery, Elizabeth ;

Horvai, Andrew E. ;

Jin, Long ;

Inwards, Carrie Y. ;

Folpe, Andrew L. .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2009, 33 (09) :1348-1354

[2] Fibroblast growth factor receptor 1 (FGFR1) is over-expressed in benign prostatic hyperplasia whereas FGFR2-IIIc and FGFR3 are not [J].

Boget, S ;

Cereser, C ;

Parvaz, P ;

Leriche, A ;

Revol, A .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2001, 145 (03) :303-310

[3] Tumor-induced osteomalacia [J].

Chong, William H. ;

Molinolo, Alfredo A. ;

Chen, Clara C. ;

Collins, Michael T. .

ENDOCRINE-RELATED CANCER, 2011, 18 (03) :R53-R77

[4] Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity - An analysis of 32 cases and a comprehensive review of the literature [J].

Folpe, AL ;

Fanburg-Smith, JC ;

Billings, SD ;

Bisceglia, M ;

Bertoni, F ;

Cho, JY ;

Econs, MJ ;

Inwards, CY ;

de Beur, SMJ ;

Mentzel, T ;

Montgomery, E ;

Michal, M ;

Miettinen, M ;

Mills, SE ;

Reith, JD ;

O'Connell, JX ;

Rosenberg, AE ;

Rubin, BP ;

Sweet, DE ;

Vinh, TN ;

Wold, LE ;

Wehrli, BM ;

White, FKE ;

Zaino, RJ ;

Weiss, SW .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2004, 28 (01) :1-30

[5] Fibroblast growth factors 1, 2, 17, and 19 are the predominant FGF ligands expressed in human fetal growth plate cartilage [J].

Krejci, Pavel ;

Krakow, Deborah ;

Mekikian, Pertchoui B. ;

Wilcox, William R. .

PEDIATRIC RESEARCH, 2007, 61 (03) :267-272

[6]

LAROCHE M, 1991, J RHEUMATOL, V18, P106

[7] Oncogenic Osteomalacia due to FGF23-Expressing Colon Adenocarcinoma [J].

Leaf, David E. ;

Pereira, Renata C. ;

Bazari, Hasan ;

Jueppner, Harald .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 98 (03) :887-891

[8] Unique morphologic and clinical features of liver predominant/primary small cell carcinoma-autopsy and biopsy case series [J].

Lo, Amy A. ;

Lo, Edward C. ;

Li, Haonan ;

Zhang, Wanying ;

Liao, Jie ;

Rao, M. Sambasivia ;

Miller, Frank ;

Yang, Guang-Yu .

ANNALS OF DIAGNOSTIC PATHOLOGY, 2014, 18 (03) :151-156

[9] Advanced prostate cancer as a cause of oncogenic osteomalacia: an underdiagnosed condition [J].

Mak, Milena Perez ;

da Costa e Silva, Veronica Torres ;

Martin, Regina Matsunaga ;

Lerario, Antonio Marcondes ;

Yu, Luis ;

Gehm Hoff, Paulo Marcelo ;

de Castro Junior, Gilberto .

SUPPORTIVE CARE IN CANCER, 2012, 20 (09) :2195-2197

[10] ONCOGENIC OSTEOMALACIA ASSOCIATED WITH METASTATIC PROSTATE CARCINOMA - CASE-REPORT AND REVIEW OF THE LITERATURE [J].

MCMURTRY, CT ;

GODSCHALK, M ;

MALLUCHE, HH ;

GENG, ZP ;

ADLER, RA .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1993, 41 (09) :983-985