Serum amyloid P: a systemic regulator of the innate immune response

被引：76
作者：
Cox, Nehemiah [1 ]
Pilling, Darrell [1 ]
Gomer, Richard H. [1 ]
机构：
[1] Texas A&M Univ, Dept Biol, College Stn, TX 77843 USA
来源：
JOURNAL OF LEUKOCYTE BIOLOGY | 2014年 / 96卷 / 05期
关键词：
neutrophil adhesion; macrophage polarization; fibrocyte differentiation; Fc gamma receptors; phagocytosis; fibrosis; INDUCED PULMONARY-FIBROSIS; FC-GAMMA RECEPTORS; C-REACTIVE PROTEIN; TUMOR-ASSOCIATED MACROPHAGES; NEUTROPHIL ELASTASE; COMPONENT; ACTIVATION; DIFFERENTIATION; POLARIZATION; FIBROCYTES;
D O I：
10.1189/jlb.1MR0114-068R
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The pentraxin SAP reduces neutrophil adhesion to ECM proteins, inhibits the differentiation of monocytes into fibrocytes, attenuates profibrotic macrophages, activates the complement pathway, and promotes phagocytosis of cell debris. Together, these effects of SAP regulate key aspects of inflammation and set a threshold for immune cell activation. Here, we present a review of SAP biology with an emphasis on SAP receptor interactions and how the effect of SAP on monocytes and macrophages has been explored to develop this protein as a therapeutic for renal and lung injuries. We also discuss how there remain many unanswered questions about the role of SAP in innate immunity.
引用
收藏
页码：739 / 743
页数：5
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