Acute superior oblique palsy in the monkey: effects of viewing conditions on ocular alignment and modelling of the ocular motor plant

被引：11

作者：

Quaia, Christian

Shan, Xiaoyan ^{[1
]}

Tian, Jing ^{[1
]}

Ying, Howard ^{[1
]}

Optican, Lance M. ^{[2
]}

Walker, Mark ^{[3
,4
,5
,6
]}

Tamargo, Rafael ^{[1
]}

Zee, David S. ^{[1
]}

机构：

[1] Johns Hopkins Univ Hosp, Dept Neurol, Baltimore, MD 21287 USA

[2] NEI, Sensorimotor Res Lab, NIH, DHHS, Bethesda, MD 20892 USA

[3] Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21218 USA

[4] Johns Hopkins Univ, Dept Ophthalmol, Baltimore, MD USA

[5] Case Western Reserve Univ, Dept Neurol, Daroff DellOsso Lab, Vet Affairs Med Ctr, Cleveland, OH 44106 USA

[6] Case Western Reserve Univ, Univ Hosp, Cleveland, OH 44106 USA

来源：

USING EYE MOVEMENTS AS AN EXPERIMENTAL PROBE OF BRAIN FUNCTION - A SYMPOSIUM IN HONOR OF JEAN BUTTNER-ENNEVER | 2008年 / 171卷

关键词：

superior oblique palsy; strabismus; eye plant; ocular motor; adaptation; eye movements; TROCHLEAR NERVE PALSY; HEAD-TILT TEST; OCULOMOTOR PLANT; MUSCLE PATHS; POSITION; PULLEYS; LAW;

D O I：

10.1016/S0079-6123(08)00607-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the immediate and long-term changes in static eye alignment with acute superior oblique palsy (SOP) in the monkey. When the paretic eye was patched immediately after the lesion for 6-9 days, vertical alignment slowly improved. When the patch was removed and binocular viewing was allowed, alignment slowly worsened. In contrast when a monkey was not patched immediately after the lesion vertical alignment did not improve. We also show that a model of the eye plant can reproduce the observed acute deficit induced by SOP, but only by abandoning Robinson's symmetric simplification of the reciprocal innervation relationship within pairs of agonist-antagonist muscles. The model also demonstrated that physiologic variability in orbital geometry can have a large impact on SOP deficits.

引用

页码：47 / 52

页数：6

共 26 条

[1] Clinical features of congenital absence of the superior oblique muscle as demonstrated by orbital imaging [J].