Estrogen regulation of placental angiogenesis and fetal ovarian development during primate pregnancy

被引:132
作者
Albrecht, Eugene D. [1 ]
Pepe, Gerald J. [2 ]
机构
[1] Univ Maryland, Sch Med, Ctr Studies Reprod, Dept Obstet Gynecol & Reprod Sci, Baltimore, MD 21201 USA
[2] Eastern Virginia Med Sch, Dept Physiol Sci, Norfolk, VA 23501 USA
关键词
placenta; estrogen; angiogenesis; fetus; ovary; ENDOTHELIAL GROWTH-FACTOR; GROWTH/PERMEABILITY FACTOR EXPRESSION; HUMAN FETOPLACENTAL VASCULOGENESIS; PRENATAL TESTOSTERONE TREATMENT; VILLOUS ANGIOPOIETIN-1 AND-2; ACUTE TEMPORAL REGULATION; RECEPTOR TYROSINE KINASE; BREAST-CANCER CELLS; GRANULOSA-CELLS; GERM-CELLS;
D O I
10.1387/ijdb.082758ea
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
During human and nonhuman primate pregnancy, an extensive blood vessel network is established within the villous placenta to support fetal growth and follicles develop within the fetal ovary to provide a pool of oocytes for reproductive function in adulthood. These two important developmental events occur in association with a progressive increase in placental estrogen production and levels. This review will describe the developmental processes required for placental vascularization and fetal follicular maturation and recent studies which show that estrogen has an important role in regulating these events.
引用
收藏
页码:397 / 407
页数:11
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