Urinary Biomarkers for Early Diagnosis of Lung Cancer

被引：7
作者：
Gasparri, Roberto [1 ]
Sedda, Giulia [1 ]
Caminiti, Valentina [1 ]
Maisonneuve, Patrick [2 ]
Prisciandaro, Elena [1 ]
Spaggiari, Lorenzo [1 ,3 ]
机构：
[1] IRCCS, European Inst Oncol, IEO, Dept Thorac Surg, Via Giuseppe Ripamonti 435, I-20141 Milan, Italy
[2] IRCCS, European Inst Oncol, IEO, Div Epidemiol & Biostat, Via Giuseppe Ripamonti 435, I-20141 Milan, Italy
[3] Univ Milan, Dept Oncol & Hematooncol, Via Festa Perdono 7, I-20122 Milan, Italy
来源：
JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 08期
关键词：
lung cancer; urine; biomarker; early diagnosis; MARKER;
D O I：
10.3390/jcm10081723
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Lung cancer is the leading cause of cancer deaths worldwide. Its early detection has the potential to significantly impact the burden of the disease. The screening and diagnostic techniques in current use suffer from limited specificity. The need therefore arises for a reliable biomarker to identify the disease earlier, which can be integrated into a test. This test would also allow for the recurrence risk after surgery to be stratified. In this context, urine could represent a non-invasive alternative matrix, with the urinary metabolomic profile offering a potential source for the discovery of diagnostic biomarkers. This paper aims to examine the current state of research and the potential for translation into clinical practice.
引用
收藏
页数：9
相关论文
共 45 条
[1]   Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening [J].
Aberle, Denise R. ;
Adams, Amanda M. ;
Berg, Christine D. ;
Black, William C. ;
Clapp, Jonathan D. ;
Fagerstrom, Richard M. ;
Gareen, Ilana F. ;
Gatsonis, Constantine ;
Marcus, Pamela M. ;
Sicks, JoRean D. .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (05) :395-409
[2]   Can dogs smell lung cancer? First study using exhaled breath and urine screening in unselected patients with suspected lung cancer [J].
Amundsen, Tore ;
Sundstrom, Stein ;
Buvik, Turid ;
Gederaas, Odrun Arna ;
Haaverstad, Rune .
ACTA ONCOLOGICA, 2014, 53 (03) :307-315
[3]   Disease Detection with Molecular Biomarkers: From Chemistry of Body Fluids to Nature-Inspired Chemical Sensors [J].
Broza, Yoav Y. ;
Zhou, Xi ;
Yuan, Miaomiao ;
Qu, Danyao ;
Zheng, Youbing ;
Vishinkin, Rotem ;
Khatib, Muhammad ;
Wu, Weiwei ;
Haick, Hossam .
CHEMICAL REVIEWS, 2019, 119 (22) :11761-11817
[4]   Predicting lung cancer prognosis using machine learning [J].
Burki, Talha Khan .
LANCET ONCOLOGY, 2016, 17 (10) :E421-E421
[5]   Current Trends in Cancer Biottiarker Discovery Using Urinary Metabolomics: Achievements and New Challenges [J].
Burton, Casey ;
Ma, Yinfa .
CURRENT MEDICINAL CHEMISTRY, 2019, 26 (01) :5-28
[6]   Metabolic Signatures of Lung Cancer in Biofluids: NMR-Based Metabonomics of Urine [J].
Carrola, Joana ;
Rocha, Claudia M. ;
Barros, Antonio S. ;
Gil, Ana M. ;
Goodfellow, Brian J. ;
Carreira, Isabel M. ;
Bernardo, Joao ;
Gomes, Ana ;
Sousa, Vitor ;
Carvalho, Lina ;
Duarte, Iola F. .
JOURNAL OF PROTEOME RESEARCH, 2011, 10 (01) :221-230
[7]   Spatial and temporal diversity in genomic instability processes defines lung cancer evolution [J].
de Bruin, Elza C. ;
McGranahan, Nicholas ;
Mitter, Richard ;
Salm, Max ;
Wedge, David C. ;
Yates, Lucy ;
Jamal-Hanjani, Mariam ;
Shafi, Seema ;
Murugaesu, Nirupa ;
Rowan, Andrew J. ;
Groenroos, Eva ;
Muhammad, Madiha A. ;
Horswell, Stuart ;
Gerlinger, Marco ;
Varela, Ignacio ;
Jones, David ;
Marshall, John ;
Voet, Thierry ;
Van Loo, Peter ;
Rassl, Doris M. ;
Rintoul, Robert C. ;
Janes, Sam M. ;
Lee, Siow-Ming ;
Forster, Martin ;
Ahmad, Tanya ;
Lawrence, David ;
Falzon, Mary ;
Capitanio, Arrigo ;
Harkins, Timothy T. ;
Lee, Clarence C. ;
Tom, Warren ;
Teefe, Enock ;
Chen, Shann-Ching ;
Begum, Sharmin ;
Rabinowitz, Adam ;
Phillimore, Benjamin ;
Spencer-Dene, Bradley ;
Stamp, Gordon ;
Szallasi, Zoltan ;
Matthews, Nik ;
Stewart, Aengus ;
Campbell, Peter ;
Swanton, Charles .
SCIENCE, 2014, 346 (6206) :251-256
[8]   Cancer metabolomic markers in urine: evidence, techniques and recommendations [J].
Dinges, Sarah S. ;
Hohm, Annika ;
Vandergrift, Lindsey A. ;
Nowak, Johannes ;
Habbel, Piet ;
Kaltashov, Igor A. ;
Cheng, Leo L. .
NATURE REVIEWS UROLOGY, 2019, 16 (06) :339-362
[9]   Nitric Oxide Metabolites and Lung Cancer Incidence: A Matched Case-Control Study Nested in the ESTHER Cohort [J].
Gao, Xin ;
Xuan, Yang ;
Benner, Axel ;
Anusruti, Ankita ;
Brenner, Hermann ;
Schoettker, Ben .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2019, 2019
[10]   Urinary 8-isoprostane levels and occurrence of lung, colorectal, prostate, breast and overall cancer: Results from a large, population-based cohort study with 14 years of follow-up [J].
Gao, Xin ;
Brenner, Hermann ;
Holleczek, Bernd ;
Cuk, Katarina ;
Zhang, Yan ;
Anusruti, Ankita ;
Xuan, Yang ;
Xu, Yiwei ;
Schottker, Ben .
FREE RADICAL BIOLOGY AND MEDICINE, 2018, 123 :20-26
12345