Conformational Switching of G-Quadruplex DNA by Photoregulation

被引：113

作者：

Wang, Xiaolin ^{[1
]}

Huang, Jing ^{[1
]}

Zhou, Yangyang ^{[1
]}

Yan, Shengyong ^{[1
]}

Weng, Xiaocheng ^{[1
]}

Wu, Xiaojun ^{[1
]}

Deng, Minggang ^{[1
]}

Zhou, Xiang ^{[1
,2
,3
]}

机构：

[1] Wuhan Univ, Key Lab Biomed Polymers, Minist Educ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[3] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 31期

关键词：

azobenzene; circular dichroism; DNA; G-quadruplexes; photoregulation; AZOBENZENE; LIGHT; PHOTOISOMERIZATION; IRRADIATION; PORPHYRIN; MACHINE; RELEASE; PH;

D O I：

10.1002/anie.201002290

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bend and stretch. . . bend and stretch. . . An azobenzene derivative was used to induce reversible stretching and folding of G-quadruplex DNA upon photoirradiation (see picture). The G-quadruplex formed in the presence of the trans isomer was dissociated by irradiation with UV light, and the resulting open oligomer was refolded into a G quadruplex under visible light. This nanodevice thus converts light directly into mechanical work. (Figure Presented). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5305 / 5309

页数：5

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