Fluorescent ion-selective nanosensors for intracellular analysis with improved lifetime and size

被引：61
作者：
Dubach, J. Matthew [1 ]
Harjes, Daniel I. [1 ]
Clark, Heather A. [1 ]
机构：
[1] Charles Stark Draper Lab Inc, Bioengn Grp, Cambridge, MA 02139 USA
来源：
NANO LETTERS | 2007年 / 7卷 / 06期
关键词：
D O I：
10.1021/nl0707860
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We describe the synthesis and characterization of sodium-selective polymeric nanosensors that improves upon the lifetime and size of previous fiberless nanosensors. Sonication is used to form the polymer nanospheres that contain all the components needed for ion sensing. Even though the size is small (approximately 120 nm), the lifetime of these sensors in solution is on the order of a week. The surface coating has also been optimized for stability, biocompatibility, and ease of chemical modification.
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页码：1827 / 1831
页数：5
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