New peptide labels containing covalently bonded platinum(II) centers as diagnostic biomarkers and biosensors

被引：79

作者：

Albrecht, M ^{[1
]}

Rodríguez, G ^{[1
]}

Schoenmaker, J ^{[1
]}

van Koten, G ^{[1
]}

机构：

[1] Univ Utrecht, Debye Res Inst, Dept Met Mediated Synth, NL-3584 CH Utrecht, Netherlands

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 22期

关键词：

D O I：

10.1021/ol006484l

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Water and acid resistant arylplatinum(ll) complexes have been covalently bonded to the N-terminus of L-valine, thus providing organometallic biomolecules with excellent stability properties. Owing to the Pt-195 nucleus (I = 1/2), these building blocks are potentially versatile biomarkers (e.g., MRI), Moreover, they display efficient in vitro biosensor characteristics since they detect SO2 gas selectively and fully reversibly by an instantaneous change of the spectroscopic properties including a diagnostic Pt-195 NMR signal.

引用

页码：3461 / 3464

页数：4

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