Disfiguring Mucor irregularis Infection Cured by Amphotericin B and Itraconazole: A Case Report and Treatment Experience

被引：4
作者：
Wei, Lin-Wei [1 ,2 ]
Wang, Hong [3 ]
Song, Ying-Gai [1 ,2 ]
Yu, Jin [1 ,2 ]
机构：
[1] Peking Univ, Dept Dermatol, Hosp 1, Beijing, Peoples R China
[2] Natl Clin Res Ctr Skin & Immune Dis, Res Ctr Med Mycol, Beijing Key Lab Mol Diag Dermatoses, Beijing, Peoples R China
[3] Qingdao 6 Peoples Hosp, Dept Dermatol, 9th Fushun St, Qingdao, Shandong, Peoples R China
来源：
MYCOPATHOLOGIA | 2019年 / 184卷 / 05期
关键词：
Mucormycosis; Mucor irregularis; Amphotericin B; Itraconazole; CUTANEOUS INFECTION;
D O I：
10.1007/s11046-019-00380-5
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We report a case of primary cutaneous mucormycosis caused by Mucor irregularis. A 52-year-old male farmer was presented to our hospital with a history of progressive nodule and plaque with ulceration on the face for two and a half years. Broad, aseptate hyphae were seen in direct KOH examination and biopsy. Fungal culture showed light yellow filamentous colonies. The rRNA sequencing revealed M. irregularis was the responsible fungus. Amphotericin B in gradually increasing dose and itraconazole were administered. When the cumulative dose of amphotericin B was 1500 mg, the skin lesion improved significantly with remaining scars on the face. Then, the patient received sequential oral itraconazole treatment for 8 months. There was no recurrence up to now through follow-ups.
引用
收藏
页码：677 / 682
页数：6
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