Nanoparticle-Mediated Drug Delivery System for Pulmonary Arterial Hypertension

被引：21

作者：

Nakamura, Kazufumi ^{[1
]}

Matsubara, Hiromi ^{[2
]}

Akagi, Satoshi ^{[1
]}

Sarashina, Toshihiro ^{[1
]}

Ejiri, Kentaro ^{[1
]}

Kawakita, Norifumi ^{[1
]}

Yoshida, Masashi ^{[1
]}

Miyoshi, Toru ^{[1
]}

Watanabe, Atsuyuki ^{[1
]}

Nishii, Nobuhiro ^{[1
]}

Ito, Hiroshi ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cardiovasc Med, Kita Ku, 2-5-1 Shikata Cho, Okayama 7008558, Japan

[2] Natl Hosp Org Okayama Med Ctr, Div Cardiol, Okayama 7011192, Japan

来源：

JOURNAL OF CLINICAL MEDICINE | 2017年 / 6卷 / 05期

关键词：

pulmonary arterial hypertension; prostacyclin; nanoparticle; drug delivery system; SMOOTH-MUSCLE-CELLS; RHO-KINASE INHIBITOR; INCORPORATED NANOPARTICLES; TRANSLATIONAL RESEARCH; IMATINIB MESYLATE; MONOCROTALINE; PROLIFERATION; THERAPY; SODIUM;

D O I：

10.3390/jcm6050048

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nanoparticles have been used as a novel drug delivery system. Drug-incorporated nanoparticles for local delivery might optimize the efficacy and minimize the side effects of drugs. The efficacy and safety of intratracheal administration of prostacyclin analog (beraprost) - incorporated nanoparticles and imatinib (a PDGF-receptor tyrosine kinase inhibitor) -incorporated nanoparticles in Sugen-hypoxia-normoxia or monocrotaline rat models of pulmonary arterial hypertension (PAH) and in human PAH-pulmonary arterial smooth muscle cells have been reported. The use of inhaled drug-incorporated nanoparticles might be a novel approach for the treatment of PAH.

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页数：6

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