What's So Special about RB?

被引:5
作者
Burd, Christin E. [1 ,2 ]
Sharpless, Norman E. [1 ,2 ,3 ]
机构
[1] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Dept Genet, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Curriculum Toxicol, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Dept Med, Chapel Hill, NC 27599 USA
关键词
CELLULAR SENESCENCE; EXPRESSION; P130; PRB;
D O I
10.1016/j.ccr.2010.03.010
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
RB, p107, and p130 are highly related proteins, each capable of regulating cellular proliferation. However, only RB is frequently mutated in cancer. In this issue of Cancer Cell, Chicas et al. shed new light on this conundrum, defining a "special," nonredundant role for RB in promoting cellular senescence.
引用
收藏
页码:313 / 314
页数:2
相关论文
共 10 条
[1]   Regulation of RB Transcription In Vivo by RB Family Members [J].
Burkhart, Deborah L. ;
Ngai, Lynn K. ;
Roake, Caitlin M. ;
Viatour, Patrick ;
Thangavel, Chellappagounder ;
Ho, Victoria M. ;
Knudsen, Erik S. ;
Sage, Julien .
MOLECULAR AND CELLULAR BIOLOGY, 2010, 30 (07) :1729-1745
[2]   Cellular senescence: when bad things happen to good cells [J].
Campisi, Judith ;
di Fagagna, Fabrizio d'Adda .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (09) :729-740
[3]   Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence [J].
Chicas, Agustin ;
Wang, Xiaowo ;
Zhang, Chaolin ;
McCurrach, Mile ;
Zhao, Zhen ;
Mert, Ozlem ;
Dickins, Ross A. ;
Narita, Masashi ;
Zhang, Michael ;
Lowe, Scott W. .
CANCER CELL, 2010, 17 (04) :376-387
[4]   Kinase-independent function of cyclin E [J].
Geng, Yan ;
Lee, Young-Mi ;
Welcker, Markus ;
Swanger, Jherek ;
Zagozdzon, Agnieszka ;
Winer, Joel D. ;
Roberts, James M. ;
Kaldis, Philipp ;
Clurman, Bruce E. ;
Sicinski, Piotr .
MOLECULAR CELL, 2007, 25 (01) :127-139
[5]   The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium [J].
Haigis, K ;
Sage, J ;
Glickman, J ;
Shafer, S ;
Jacks, T .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (01) :638-647
[6]  
Herrera RE, 1996, MOL CELL BIOL, V16, P2402
[7]   pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes [J].
Hurford, RK ;
Cobrinik, D ;
Lee, MH ;
Dyson, N .
GENES & DEVELOPMENT, 1997, 11 (11) :1447-1463
[8]   Distinct roles for p107 and p130 in Rb-independent cellular senescence [J].
Lehmann, Brian D. ;
Brooks, Adam M. ;
Paine, Matthew S. ;
Chappell, William H. ;
McCubrey, James A. ;
Terrian, David M. .
CELL CYCLE, 2008, 7 (09) :1262-1268
[9]   Unique Impact of RB Loss on Hepatic Proliferation TUMORIGENIC STRESSES UNCOVER DISTINCT PATHWAYS OF CELL CYCLE CONTROL [J].
Reed, Christopher A. ;
Mayhew, Christopher N. ;
McClendon, A. Kathleen ;
Knudsen, Erik S. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (02) :1089-1096
[10]   Retinoblastoma/p107/p130 Pocket Proteins PROTEIN DYNAMICS AND INTERACTIONS WITH TARGET GENE PROMOTERS [J].
Stengel, Kristy R. ;
Thangavel, Chellappagounder ;
Solomon, David A. ;
Angus, Steve P. ;
Zheng, Yi ;
Knudsen, Erik S. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (29) :19265-19271