Signaling by activated protein C in endothelial cells is PAR1 dependent but distinct from thrombin signaling.

被引:0
|
作者
Riewald, M [1 ]
Feistritzer, C [1 ]
Ruf, W [1 ]
机构
[1] Scripps Res Inst, Dept Immunol, La Jolla, CA USA
关键词
D O I
10.1182/blood.V104.11.221.221
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
221
引用
收藏
页码:67A / 67A
页数:1
相关论文
共 50 条
  • [1] PAR1 cleavage and signaling in response to activated protein C and thrombin
    Ludeman, MJ
    Kataoka, H
    Srinivasan, Y
    Esmon, NL
    Esmon, CT
    Coughlin, SR
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (13) : 13122 - 13128
  • [2] Dose dependent effects of PAR1 signaling by the protein C pathway and by thrombin on endothelial permeability
    Feistritzer, C
    Lenta, R
    Riewald, M
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (05) : E66 - E66
  • [3] Activated protein C signals through the thrombin receptor PAR1 in endothelial cells
    Riewald, M
    Petrovan, RJ
    Donner, A
    Ruf, W
    JOURNAL OF ENDOTOXIN RESEARCH, 2003, 9 (05): : 317 - 321
  • [4] Activated protein C signals through the thrombin receptor PAR1 in endothelial cells
    Riewald, M
    Petrovan, RJ
    Donner, A
    Ruf, W
    FASEB JOURNAL, 2002, 16 (04): : A589 - A590
  • [5] Activated factor X cleaves PAR1 and mediates signaling dependent on binding to the endothelial protein C receptor
    Schuepbach, R. A.
    Riewald, M.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 : 85 - 85
  • [6] Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling
    Riewald, M
    Ruf, W
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (20) : 19808 - 19814
  • [7] Regulation of activated Protein C/PAR1 endothelial cytoprotective signaling by G protein-coupled receptor kinases
    Ramirez, Monica L. Gonzalez
    Lin, Ying
    Qin, Huaping
    Birch, Cierra
    Trejo, JoAnn
    FASEB JOURNAL, 2022, 36
  • [8] Thrombin Regulates the Metastatic Potential of Human Rhabdomyosarcoma Cells: Distinct Role of PAR1 and PAR3 Signaling
    Wysoczynski, Marcin
    Liu, Rui
    Kucia, Magda
    Drukala, Justyna
    Ratajczak, Mariusz Z.
    MOLECULAR CANCER RESEARCH, 2010, 8 (05) : 677 - 690
  • [9] Unravelling PAR1 signaling in endothelial cells using quantitative phosphoproteomics
    van den Eshof, B. L.
    van Alphen, F. P.
    Mertens, K.
    Meijer, A. B.
    van den Biggelaar, M.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2015, 13 : 21 - 21
  • [10] PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke
    Sinha, Ranjeet K.
    Wang, Yaoming
    Zhao, Zhen
    Xu, Xiao
    Burnier, Laurent
    Gupta, Naveen
    Fernandez, Jose A.
    Martin, Greg
    Kupriyanov, Sergey
    Mosnier, Laurent O.
    Zlokovic, Berislav V.
    Griffin, John H.
    BLOOD, 2018, 131 (11) : 1163 - 1171