Regulation of autophagy by VPS34 branched ubiquitination controls proteostasis and liver metabolism

被引：0

作者：

Chen, Yu-Hsuan ^{[1
]}

Chen, Ruey-Hwa ^{[1
]}

机构：

[1] Acad Sinica, Inst Biol Chem, Taipei 115, Taiwan

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2021年 / 8卷 / 03期

关键词：

Autophagy; branched ubiquitination; vps34; liver steatosis; protein quality control;

D O I：

10.1080/23723556.2021.1915076

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ubiquitin-proteasome system and autophagy are the two major recycling processes. Our recent work uncovers a K29/K48 branched ubiquitination on the phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3KC3, best known as VPS34). This ubiquitination is positively or negatively regulated under pathophysiological conditions to influence on autophagy, proteostasis and lipid homeostasis.

引用

页数：3

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