Regulation of autophagy by VPS34 branched ubiquitination controls proteostasis and liver metabolism

被引：0
|
作者：
Chen, Yu-Hsuan [1 ]
Chen, Ruey-Hwa [1 ]
机构：
[1] Acad Sinica, Inst Biol Chem, Taipei 115, Taiwan
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2021年 / 8卷 / 03期
关键词：
Autophagy; branched ubiquitination; vps34; liver steatosis; protein quality control;
D O I：
10.1080/23723556.2021.1915076
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ubiquitin-proteasome system and autophagy are the two major recycling processes. Our recent work uncovers a K29/K48 branched ubiquitination on the phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3KC3, best known as VPS34). This ubiquitination is positively or negatively regulated under pathophysiological conditions to influence on autophagy, proteostasis and lipid homeostasis.
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页数：3
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