MicroRNAs and prostate cancer

被引：114
作者：
Coppola, Valeria [1 ]
De Maria, Ruggero [1 ,2 ]
Bonci, Desiree [1 ]
机构：
[1] Ist Super Sanita, Dept Hematol Oncol & Mol Med, I-00161 Rome, Italy
[2] Mediterranean Inst Oncol, Dept Expt Oncol, I-95029 Catania, Italy
来源：
ENDOCRINE-RELATED CANCER | 2010年 / 17卷 / 01期
关键词：
TUMOR-SUPPRESSOR GENE; GROUP PROTEIN EZH2; DOWN-REGULATION; C-MYC; ANDROGEN RECEPTOR; EXPRESSION PROFILES; WNT/BETA-CATENIN; RNA-INTERFERENCE; GROWTH ARREST; PIVOTAL ROLE;
D O I：
10.1677/ERC-09-0172
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Despite much progress in prostate cancer management, new diagnostic, prognostic and therapeutic tools are needed to predict disease severity, choose among the available treatments and establish more effective therapies for advanced prostate cancer. In the last few years, compelling evidence has documented the role of microRNAs as new broad-spectrum oncogenes or tumour suppressor genes, thus their use as diagnostic, prognostic and therapeutic biomolecules is envisaged. This review extensively and critically summarizes the current knowledge about microRNA deregulation in prostate cancer disease, underlining present limits and future perspectives.
引用
收藏
页码：F1 / F17
页数：17
相关论文
共 161 条
[41]   miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1* [J].
Galardi, Silvia ;
Mercatelli, Neri ;
Giorda, Ezio ;
Massalini, Simone ;
Frajese, Giovanni Vanni ;
Ciafre, Silvia Anna ;
Farace, Maria Giulia .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (32) :23716-23724
[42]   miR-205 Exerts Tumor-Suppressive Functions in Human Prostate through Down-regulation of Protein Kinase Cε [J].
Gandellini, Paolo ;
Folini, Marco ;
Longoni, Nicole ;
Pennati, Marzia ;
Binda, Mara ;
Colecchia, Maurizio ;
Salvioni, Roberto ;
Supino, Rosanna ;
Moretti, Roberta ;
Limonta, Patrizia ;
Valdagni, Riccardo ;
Daidone, Maria Grazia ;
Zaffaroni, Nadia .
CANCER RESEARCH, 2009, 69 (06) :2287-2295
[43]   MicroRNAs: key regulators of stem cells [J].
Gangaraju, Vamsi K. ;
Lin, Haifan .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2009, 10 (02) :116-125
[44]   c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism [J].
Gao, Ping ;
Tchernyshyov, Irina ;
Chang, Tsung-Cheng ;
Lee, Yun-Sil ;
Kita, Kayoko ;
Ochi, Takafumi ;
Zeller, Karen I. ;
De Marzo, Angelo M. ;
Van Eyk, Jennifer E. ;
Mendell, Joshua T. ;
Dang, Chi V. .
NATURE, 2009, 458 (7239) :762-U100
[45]   Serum MicroRNAs Are Promising Novel Biomarkers [J].
Gilad, Shlomit ;
Meiri, Eti ;
Yogev, Yariv ;
Benjamin, Sima ;
Lebanony, Danit ;
Yerushalmi, Noga ;
Benjamin, Hila ;
Kushnir, Michal ;
Cholakh, Hila ;
Melamed, Nir ;
Bentwich, Zvi ;
Hod, Moshe ;
Goren, Yaron ;
Chajut, Ayelet .
PLOS ONE, 2008, 3 (09)
[46]   Micro-RNA profiling in kidney and bladder cancers [J].
Gottardo, Fedra ;
Liu, Chang Gong ;
Ferracin, Manuela ;
Calin, George A. ;
Fassan, Mattect ;
Bassi, Pierfrancesco ;
Sevignani, Cinzia ;
Byrne, Dolores ;
Negrini, Massimo ;
Pagano, Francesco ;
Gomella, Leonard G. ;
Croce, Carlo M. ;
Baffa, Raffaele .
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2007, 25 (05) :387-392
[47]   Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression [J].
Graff, JR ;
Konicek, BW ;
McNulty, AM ;
Wang, ZJ ;
Houck, K ;
Allen, S ;
Paul, JD ;
Hbaiu, A ;
Goode, RG ;
Sandusky, GE ;
Vessella, RL ;
Neubauer, BL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (32) :24500-24505
[48]   Prostate cancer epidemiology [J].
Grönberg, H .
LANCET, 2003, 361 (9360) :859-864
[49]  
HE L, 2004, NATURE REV GENETICS, V5, P522
[50]   A microRNA component of the p53 tumour suppressor network [J].
He, Lin ;
He, Xingyue ;
Lim, Lee P. ;
De Stanchina, Elisa ;
Xuan, Zhenyu ;
Liang, Yu ;
Xue, Wen ;
Zender, Lars ;
Magnus, Jill ;
Ridzon, Dana ;
Jackson, Aimee L. ;
Linsley, Peter S. ;
Chen, Caifu ;
Lowe, Scott W. ;
Cleary, Michele A. ;
Hannon, Gregory J. .
NATURE, 2007, 447 (7148) :1130-U16
12345678910