MicroRNAs and prostate cancer

被引：114

作者：

Coppola, Valeria ^{[1
]}

De Maria, Ruggero ^{[1
,2
]}

Bonci, Desiree ^{[1
]}

机构：

[1] Ist Super Sanita, Dept Hematol Oncol & Mol Med, I-00161 Rome, Italy

[2] Mediterranean Inst Oncol, Dept Expt Oncol, I-95029 Catania, Italy

来源：

关键词：

TUMOR-SUPPRESSOR GENE; GROUP PROTEIN EZH2; DOWN-REGULATION; C-MYC; ANDROGEN RECEPTOR; EXPRESSION PROFILES; WNT/BETA-CATENIN; RNA-INTERFERENCE; GROWTH ARREST; PIVOTAL ROLE;

D O I：

10.1677/ERC-09-0172

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite much progress in prostate cancer management, new diagnostic, prognostic and therapeutic tools are needed to predict disease severity, choose among the available treatments and establish more effective therapies for advanced prostate cancer. In the last few years, compelling evidence has documented the role of microRNAs as new broad-spectrum oncogenes or tumour suppressor genes, thus their use as diagnostic, prognostic and therapeutic biomolecules is envisaged. This review extensively and critically summarizes the current knowledge about microRNA deregulation in prostate cancer disease, underlining present limits and future perspectives.

引用

页码：F1 / F17

页数：17

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