MicroRNAs and prostate cancer

被引：114
作者：
Coppola, Valeria [1 ]
De Maria, Ruggero [1 ,2 ]
Bonci, Desiree [1 ]
机构：
[1] Ist Super Sanita, Dept Hematol Oncol & Mol Med, I-00161 Rome, Italy
[2] Mediterranean Inst Oncol, Dept Expt Oncol, I-95029 Catania, Italy
来源：
ENDOCRINE-RELATED CANCER | 2010年 / 17卷 / 01期
关键词：
TUMOR-SUPPRESSOR GENE; GROUP PROTEIN EZH2; DOWN-REGULATION; C-MYC; ANDROGEN RECEPTOR; EXPRESSION PROFILES; WNT/BETA-CATENIN; RNA-INTERFERENCE; GROWTH ARREST; PIVOTAL ROLE;
D O I：
10.1677/ERC-09-0172
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Despite much progress in prostate cancer management, new diagnostic, prognostic and therapeutic tools are needed to predict disease severity, choose among the available treatments and establish more effective therapies for advanced prostate cancer. In the last few years, compelling evidence has documented the role of microRNAs as new broad-spectrum oncogenes or tumour suppressor genes, thus their use as diagnostic, prognostic and therapeutic biomolecules is envisaged. This review extensively and critically summarizes the current knowledge about microRNA deregulation in prostate cancer disease, underlining present limits and future perspectives.
引用
收藏
页码：F1 / F17
页数：17
相关论文
共 161 条
[1]   Transcriptional regulation and transformation by MYC proteins [J].
Adhikary, S ;
Eilers, M .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (08) :635-645
[2]   Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer [J].
Akashi, Takuya ;
Koizumi, Keiichi ;
Tsuneyama, Koichi ;
Saiki, Ikuo ;
Takano, Yasuo ;
Fuse, Hideki .
CANCER SCIENCE, 2008, 99 (03) :539-542
[3]   Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by β-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT [J].
Almeida, M ;
Han, L ;
Bellido, T ;
Manolagas, SC ;
Kousteni, S .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (50) :41342-41351
[4]   Genomic profiling of MicroRNA and messenger RNA reveals deregulated MicroRNA expression in prostate cancer [J].
Ambs, Stefan ;
Prueitt, Robyn L. ;
Yi, Ming ;
Hudson, Robert S. ;
Howe, Tiffany M. ;
Petrocca, Fabio ;
Wallace, Tiffany A. ;
Liu, Chang-Gong ;
Volinia, Stefano ;
Calin, George A. ;
Yfantis, Harris G. ;
Stephens, Robert M. ;
Croce, Carlo M. .
CANCER RESEARCH, 2008, 68 (15) :6162-6170
[5]   Cross-talk unfolded:: MARCKS proteins [J].
Arbuzova, A ;
Schmitz, AAP ;
Vergères, G .
BIOCHEMICAL JOURNAL, 2002, 362 :1-12
[6]   MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer [J].
Asangani, I. A. ;
Rasheed, S. A. K. ;
Nikolova, D. A. ;
Leupold, J. H. ;
Colburn, N. H. ;
Post, S. ;
Allgayer, H. .
ONCOGENE, 2008, 27 (15) :2128-2136
[7]   MicroRNAs: new regulators of immune cell development and function [J].
Baltimore, David ;
Boldin, Mark P. ;
O'Connell, Ryan M. ;
Rao, Dinesh S. ;
Taganov, Konstantin D. .
NATURE IMMUNOLOGY, 2008, 9 (08) :839-845
[8]   MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].
Bartel, David P. .
CELL, 2007, 131 (04) :11-29
[9]  
Bernard D, 2003, J CLIN INVEST, V112, P1724
[10]   p53-mediated activation of miRNA34 candidate tumor-suppressor genes [J].
Bommer, Guido T. ;
Gerin, Isabelle ;
Feng, Ying ;
Kaczorowski, Andrew J. ;
Kuick, Rork ;
Love, Robert E. ;
Zhai, Yali ;
Giordano, Thomas J. ;
Qin, Zhaohui S. ;
Moore, Bethany B. ;
MacDougald, Ormond A. ;
Cho, Kathleen R. ;
Fearon, Eric R. .
CURRENT BIOLOGY, 2007, 17 (15) :1298-1307
12345678910