Detection and Characterization of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Isolates in Canada: Results from the Canadian Nosocomial Infection Surveillance Program, 1995-2006

被引：43

作者：

Adam, Heather J. ^{[2
]}

Louie, Lisa

Watt, Christine

Gravel, Denise ^{[3
]}

Bryce, Elizabeth ^{[4
]}

Loeb, Mark ^{[5
]}

Matlow, Anne ^{[2
,6
]}

McGeer, Allison ^{[2
,7
]}

Mulvey, Michael R. ^{[8
]}

Simor, Andrew E. ^{[1
,2
]}

机构：

[1] Sunnybrook Hlth Sci Ctr, Dept Microbiol, Toronto, ON M4N 3M5, Canada

[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[3] Publ Hlth Agcy Canada, Ctr Communicable Dis & Infect Control, Ottawa, ON, Canada

[4] Vancouver Gen Hosp, Vancouver, BC, Canada

[5] McMaster Univ, Hamilton, ON, Canada

[6] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[7] Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada

[8] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 02期

关键词：

REDUCED SUSCEPTIBILITY; NATIONAL SURVEILLANCE; CLINICAL-FEATURES; RESISTANT; BACTEREMIA; GLYCOPEPTIDES; HOSPITALS; STRAINS; HETERORESISTANCE; PERSISTENT;

D O I：

10.1128/AAC.01316-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We describe the epidemiology of heterogeneously resistant Staphylococcus aureus (hVISA) identified in Canadian hospitals between 1995 and 2006. hVISA isolates were confirmed by the population analysis profiling-area under the curve method. Only 25 hVISA isolates (1.3% of all isolates) were detected. hVISA isolates were more likely to have been health care associated (odds ratio [OR], 5.1; 95% confidence interval [CI], 1.9 to 14.2) and to have been recovered from patients hospitalized in central Canada (OR, 3.0; 95% CI, 1.2 to 7.4). There has been no evidence of vancomycin "MIC creep" in Canadian strains of methicillin (meticillin)-resistant S. aureus, and hVISA strains are currently uncommon.

引用

页码：945 / 949

页数：5

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