Antifungal activity of some amino acids complexes against Candida albicans

The development of antifungal agents has lagged behind that of antibacterial agents, because fungi generally grow slowly and often in multicellular forms, they are more difficult to quantify than bacteria. This experiment was designed to evaluate the in vitro properties of the amino acids complexes as potential antifungal agent. We tested 4 amino acid complexes: Cu-lysine, Cu-methionine, Co-lysine and Co-methionine, at different concentrations. The end-points for cytotoxicity evaluation are: proliferation rate, lactate dehidrogenase activity (LDH). These two end-points gave similar results with the proliferation rate but the last methods seem to be more sensible. Cupper complexes especially those with methionine proved to have the higher activity against Candida albicans from all the amino acids complexes.