An operational transformation of 3-carboxy-4-quinolones into 3-nitro-4-quinolones via ipso-nitration using polysaccharide supported copper nanoparticles: synthesis of 3-tetrazolyl bioisosteres of 3-carboxy-4-quinolones as antibacterial agents

被引：15

作者：

Azad, Chandra S. ^{[1
]}

Narula, Anudeep K. ^{[1
]}

机构：

[1] GGS Indraprastha Univ, Hygeia Ctr Excellence Pharmaceut Sci CEPS, Sec 16C, New Delhi, India

来源：

RSC ADVANCES | 2016年 / 6卷 / 23期

关键词：

IMMOBILIZED PALLADIUM NANOPARTICLES; RECYCLABLE HETEROGENEOUS CATALYST; SUBSTRATE PNP-SSS; EFFICIENT; CHITOSAN; SILICA; WATER; HECK; 3-NITROQUINOLINES; (E)-NITROOLEFINS;

D O I：

10.1039/c5ra26909a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chitosan supported Cu nano-particles have been synthesized, and utilized for the synthesis of 3-nitro-4-quinolones from 3-carboxy-4-quinolones via ipso nitration. The synthesized 3-nitro derivatives of 4-quinolones were successfully converted into their 3-tetrazolyl bioisosteres which showed increased antibacterial activity as compared to the standard ciprofloxacin.

引用

页码：19052 / 19059

页数：8

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