The RNA-dependent RNA polymerase of the influenza A virus

被引：35

作者：

Stubbs, Thomas M. ^{[1
,2
]}

te Velthuis, Aartjan J. W. ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

[2] Babraham Inst, Cambridge CB22 3AT, England

来源：

FUTURE VIROLOGY | 2014年 / 9卷 / 09期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

adaptation; host restriction; influenza A; replication; RNA polymerase; structure; transcription; SINGLE AMINO-ACID; PA SUBUNIT; MESSENGER-RNA; HOST-RANGE; VIRAL POLYMERASE; PB1; SUBUNIT; IN-VITRO; PANDEMIC INFLUENZA; CRYSTAL-STRUCTURE; PROMOTER-BINDING;

D O I：

10.2217/fvl.14.66

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The influenza A virus causes a highly contagious respiratory disease that significantly impacts our economy and health. Its replication and transcription is catalyzed by the viral RNA polymerase. This enzyme is also crucial for the virus, because it is involved in the adaptation of zoonotic strains. It is thus of major interest for the development of antiviral therapies and is being intensively studied. In this article, we will discuss recent advances that have improved our knowledge of the structure of the RNA polymerase and how mutations in the polymerase help the virus to spread effectively among new hosts.

引用

页码：863 / 876

页数：14

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