The RNA-dependent RNA polymerase of the influenza A virus

被引：35

作者：

Stubbs, Thomas M. ^{[1
,2
]}

te Velthuis, Aartjan J. W. ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

[2] Babraham Inst, Cambridge CB22 3AT, England

来源：

FUTURE VIROLOGY | 2014年 / 9卷 / 09期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

adaptation; host restriction; influenza A; replication; RNA polymerase; structure; transcription; SINGLE AMINO-ACID; PA SUBUNIT; MESSENGER-RNA; HOST-RANGE; VIRAL POLYMERASE; PB1; SUBUNIT; IN-VITRO; PANDEMIC INFLUENZA; CRYSTAL-STRUCTURE; PROMOTER-BINDING;

D O I：

10.2217/fvl.14.66

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The influenza A virus causes a highly contagious respiratory disease that significantly impacts our economy and health. Its replication and transcription is catalyzed by the viral RNA polymerase. This enzyme is also crucial for the virus, because it is involved in the adaptation of zoonotic strains. It is thus of major interest for the development of antiviral therapies and is being intensively studied. In this article, we will discuss recent advances that have improved our knowledge of the structure of the RNA polymerase and how mutations in the polymerase help the virus to spread effectively among new hosts.

引用

页码：863 / 876

页数：14

共 97 条

[1] Biochemical Impact of the Host Adaptation-associated PB2 E627K Mutation on the Temperature-dependent RNA Synthesis Kinetics of Influenza A Virus Polymerase Complex [J].

Aggarwal, Shilpa ;

Dewhurst, Stephen ;

Takimoto, Toru ;

Kim, Baek .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (40) :34504-34513

[2] 3D structure of the influenza virus polymerase complex:: Localization of subunit domains [J].

Area, E ;

Martín-Benito, J ;

Gastaminza, P ;

Torreira, E ;

Valpuesta, JM ;

Carrascosa, JL ;

Ortín, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (01) :308-313

[3] The Structure of Native Influenza Virion Ribonucleoproteins [J].

Arranz, Rocio ;

Coloma, Rocio ;

Javier Chichon, Francisco ;

Javier Conesa, Jose ;

Carrascosa, Jose L. ;

Valpuesta, Jose M. ;

Ortin, Juan ;

Martin-Benito, Jaime .

SCIENCE, 2012, 338 (6114) :1634-1637

[4] STRUCTURE OF INFLUENZA-VIRUS RNP .1. INFLUENZA-VIRUS NUCLEOPROTEIN MELTS SECONDARY STRUCTURE IN PANHANDLE RNA AND EXPOSES THE BASES TO THE SOLVENT [J].

BAUDIN, F ;

BACH, C ;

CUSACK, S ;

RUIGROK, RWH .

EMBO JOURNAL, 1994, 13 (13) :3158-3165

[5] MUTATIONAL ANALYSIS OF THE CONSERVED MOTIFS OF INFLUENZA-A VIRUS POLYMERASE BASIC-PROTEIN 1 [J].

BISWAS, SK ;

NAYAK, DP .

JOURNAL OF VIROLOGY, 1994, 68 (03) :1819-1826

[6] Reversion of PB2-627E to-627K during Replication of an H5N1 Clade 2.2 Virus in Mammalian Hosts Depends on the Origin of the Nucleoprotein [J].

Bogs, Jessica ;

Kalthoff, Donata ;

Veits, Jutta ;

Pavlova, Sophia ;

Schwemmle, Martin ;

Maenz, Benjamin ;

Mettenleiter, Thomas C. ;

Stech, Juergen .

JOURNAL OF VIROLOGY, 2011, 85 (20) :10691-10698

[7] Interaction of the Influenza A Virus Polymerase PB2 C-terminal Region with Importin α Isoforms Provides Insights into Host Adaptation and Polymerase Assembly [J].

Boivin, Stephane ;

Hart, Darren J. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (12) :10439-10448

[8] Host- and Strain-Specific Regulation of Influenza Virus Polymerase Activity by Interacting Cellular Proteins [J].

Bortz, Eric ;

Westera, Liset ;

Maamary, Jad ;

Steel, John ;

Albrecht, Randy A. ;

Manicassamy, Balaji ;

Chase, Geoffrey ;

Martinez-Sobrido, Luis ;

Schwemmle, Martin ;

Garcia-Sastre, Adolfo .

MBIO, 2011, 2 (04)

[9] The RNA polymerase of influenza A virus is stabilized by interaction with its viral RNA promoter [J].

Brownlee, GG ;

Sharps, JL .

JOURNAL OF VIROLOGY, 2002, 76 (14) :7103-7113

[10] A structural and primary sequence comparison of the viral RNA-dependent RNA polymerases [J].

Bruenn, JA .

NUCLEIC ACIDS RESEARCH, 2003, 31 (07) :1821-1829

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