Systemic iron reduction by venesection alters the gut microbiome in patients with haemochromatosis

被引:8
作者
Parmanand, Bhavika [1 ,2 ]
Watson, Michael [3 ,4 ]
Boland, Karen J. [5 ]
Ramamurthy, Narayan [3 ]
Wharton, Victoria [3 ,4 ]
Morovat, Alireza [6 ]
Lund, Elizabeth K. [2 ]
Collier, Jane [3 ,4 ]
Le Gall, Gwenaelle [2 ]
Kellingray, Lee [1 ]
Fairweather-Tait, Susan [2 ]
Cobbold, Jeremy F. [3 ,4 ]
Narbad, Arjan [1 ]
Ryan, John D. [3 ,7 ]
机构
[1] Quadram Inst, Norwich, Norfolk, England
[2] Univ East Anglia, Norwich, Norfolk, England
[3] Univ Oxford, Translat Gastroenterol Unit, Oxford, England
[4] NIHR Oxford Biomed Res Ctr, Oxford, England
[5] Royal Coll Surgeons Ireland, Beaumont Hosp, Dept Gastroenterol, Dublin, Ireland
[6] Oxford Univ Hosp Fdn Trust, Dept Clin Biochem, Oxford, England
[7] Royal Coll Surgeons Ireland, Beaumont Hosp, Hepatol Unit, Dublin 9, Ireland
基金
英国生物技术与生命科学研究理事会;
关键词
Microbiome; Iron; Venesection; Haemochromatosis;
D O I
10.1016/j.jhepr.2020.100154
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background & Aims: Iron reduction by venesection has been the cornerstone of treatment for haemochromatosis for decades, and its reported health benefits are many. Repeated phlebotomy can lead to a compensatory increase in intestinal iron absorption, reducing intestinal iron availability. Given that most gut bacteria are highly dependent on iron for survival, we postulated that, by reducing gut iron levels, venesection could alter the gut microbiota. Methods: Clinical parameters, faecal bacterial composition and metabolomes were assessed before and during treatment in a group of patients with haemochromatosis undergoing iron reduction therapy. Results: Systemic iron reduction was associated with an alteration of the gut microbiome, with changes evident in those who experienced reduced faecal iron availability with venesection. For example, levels of Faecalibacterium prausnitzii, a bacterium associated with improved colonic health, were increased in response to faecal iron reduction. Similarly, metabolomic changes were seen in association with reduced faecal iron levels. Conclusion: These findings highlight a significant shift in the gut microbiome of patients who experience reduced colonic iron during venesection. Targeted depletion of faecal iron could represent a novel therapy for metabolic and inflammatory diseases, meriting further investigation. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).
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页数:5
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