Therapeutic angiogenesis for severe ischemic heart diseases by autologous bone marrow cells transplantation

被引:5
作者
Hattori, R
Matsubara, H
机构
[1] Inst Jantung Negara Natl Heart Inst, Dept Cardiothorac Surg, Kuala Lumpur 50400, Malaysia
[2] Kansai Med Univ, Dept Thorac & Cardiovasc Surg, Osaka 5708507, Japan
[3] Kyoto Prefectural Univ, Sch Med, Dept Cardiovasc Med, Kamigyo Ku, Kyoto 6028566, Japan
关键词
angiogenesis; bone marrow cells; ischemic heart disease; sole therapy; transplantation;
D O I
10.1023/B:MCBI.0000044384.39422.e0
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Conventional therapies for severe ischemic heart disease are limited in applicability. While several angiogenesis researches have shown novel efficacy, safety and feasibility for clinical use, recently we have started the clinical trial of a sole cell therapy using autologous bone marrow mononuclear cells transplantation targeted into ischemic hibernating myocardium. Here, we review the background of bone marrow cell research and introduce therapeutic angiogenesis for severe ischemic heart disease by autologous bone marrow cells transplantation.
引用
收藏
页码:151 / 155
页数:5
相关论文
共 19 条
[1]   Myocyte renewal and ventricular remodelling [J].
Anversa, P ;
Nadal-Ginard, B .
NATURE, 2002, 415 (6868) :240-243
[2]   Isolation of putative progenitor endothelial cells for angiogenesis [J].
Asahara, T ;
Murohara, T ;
Sullivan, A ;
Silver, M ;
vanderZee, R ;
Li, T ;
Witzenbichler, B ;
Schatteman, G ;
Isner, JM .
SCIENCE, 1997, 275 (5302) :964-967
[3]   Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization [J].
Asahara, T ;
Masuda, H ;
Takahashi, T ;
Kalka, C ;
Pastore, C ;
Silver, M ;
Kearne, M ;
Magner, M ;
Isner, JM .
CIRCULATION RESEARCH, 1999, 85 (03) :221-228
[4]   VEGF gene therapy: stimulating angiogenesis or angioma-genesis? [J].
Carmeliet, P .
NATURE MEDICINE, 2000, 6 (10) :1102-1103
[5]  
Carmeliet P, 2001, THROMB HAEMOSTASIS, V86, P289
[6]   Clinical applications of angiogenic growth factors and their inhibitors [J].
Ferrara, N ;
Alitalo, K .
NATURE MEDICINE, 1999, 5 (12) :1359-1364
[7]   RETRACTED: Angiogenesis by implantation of peripheral blood mononuclear cells and platelets into ischemic limbs (Retracted Article) [J].
Iba, O ;
Matsubara, H ;
Nozawa, Y ;
Fujiyama, S ;
Amano, K ;
Mori, Y ;
Kojima, H ;
Iwasaka, T .
CIRCULATION, 2002, 106 (15) :2019-2025
[8]   Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization [J].
Isner, JM ;
Asahara, T .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (09) :1231-1236
[9]   Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization [J].
Kalka, C ;
Masuda, H ;
Takahashi, T ;
Kalka-Moll, WM ;
Silver, M ;
Kearney, M ;
Li, T ;
Isner, JM ;
Asahara, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3422-3427
[10]   Improvement of collateral perfusion and regional function by implantation of peripheral blood mononuclear cells into ischemic hibernating myocardium [J].
Kamihata, H ;
Matsubara, H ;
Nishiue, T ;
Fujiyama, S ;
Amano, K ;
Iba, O ;
Imada, T ;
Iwasaka, T .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (11) :1804-1810