The neurobiological characteristics of rapid eye movement (REM) sleep are candidate endophenotypes of depression, schizophrenia, mental retardation and dementia

被引：86

作者：

Gottesmann, Claude

Gottesman, Irving

机构：

[1] Univ Nice, Fac Sci, Dept Sci Vie, Nice, France

[2] Univ Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA

来源：

PROGRESS IN NEUROBIOLOGY | 2007年 / 81卷 / 04期

关键词：

mental illness; paradoxical sleep; dreaming;

D O I：

10.1016/j.pneurobio.2007.01.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Animal models are a promising method to approach the basic mechanisms of the neurobiological disturbances encountered in mental disorders. Depression is characterized by a decrease of REM sleep latency and an increase of rapid eye movement density. In schizophrenia, electro-physiological, tomographic, pharmacological and neurochemical activities are all encountered during REM sleep. Mental retardation and dementia are characterized by rather specific REM sleep disturbances. Identification of the genetic support for these abnormalities (endophenotypes) encountered during REM sleep could help to develop specific treatments, (c) 2007 Published by Elsevier Ltd.

引用

页码：237 / 250

页数：14

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[1] Prefrontal DA transmission at D1 receptors and the pathology of schizophrenia [J].