Inherited susceptibility to breast and ovarian cancer

被引：4
|
作者：
Diamond, TM [1 ]
Sutphen, R [1 ]
Tabano, M [1 ]
Fiorica, J [1 ]
机构：
[1] Univ S Florida, Dept Pediat, Tampa, FL 33620 USA
来源：
CURRENT OPINION IN OBSTETRICS & GYNECOLOGY | 1998年 / 10卷 / 01期
关键词：
D O I：
10.1097/00001703-199802000-00002
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Approximately 5-10% of breast and ovarian cancer cases are due to an inherited susceptibility. The majority of inherited breast and ovarian cancer susceptibility is due to mutations in the BRCA1 and BRCA2 genes; however, other genes responsible for inherited susceptibility to these diseases are yet to be identified. A small proportion of inherited breast and ovarian cancers are due to other genetic cancer susceptibility syndromes including Li-Fraumeni syndrome, Cowden disease and hereditary nonpolyposis colorectal cancer. It is recommended that individuals at risk for inherited susceptibility to breast and/or ovarian cancer who are requesting DNA testing be provided with pre-test genetic counseling and education and post-test counseling and follow-up to ensure that all aspects of genetic testing have been disclosed and that the patient has truly given informed consent. 1040-872X (C) 1998 Rapid Science Publishers.
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页码：3 / 8
页数：6
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