Rationally Designed Multifunctional Supramolecular Iminium Catalysis: Direct Vinylogous Michael Addition of Unmodified Linear Dienol Substrates

被引:95
作者
Gu, Yun [1 ]
Wang, Yao [1 ]
Yu, Tian-Yang [1 ]
Liang, Yong-Min [1 ]
Xu, Peng-Fei [1 ]
机构
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China
关键词
asymmetric catalysis; Michael addition; regioselectivity; supramolecular chemistry; synthetic methods; ALDOL REACTION; KETONES;
D O I
10.1002/anie.201406786
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The development of a direct vinylogous Michael addition of linear nucleophilic substrates is a long-standing challenge because of the poor reactivity and the considerable difficulty in controlling regioselectivity. By employing a rationally designed multifunctional supramolecular iminium catalysis strategy, the first direct vinylogous Michael addition of unmodified linear substrates to alpha,beta-unsaturated aldehydes, to afford chiral 1,7-dioxo compounds with good yields and excellent regio- as well as enantioselectivity, has been developed.
引用
收藏
页码:14128 / 14131
页数:4
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