Magnesium and the blood-brain barrier in vitro: effects on permeability and magnesium transport

被引：22
作者：
Romeo, Valentina [1 ]
Cazzaniga, Alessandra [1 ]
Maier, Jeanette A. M. [1 ]
机构：
[1] Univ Milan, Dipartimento Sci Biomed & Clin L Sacco, Via GB Grassi 74, I-20157 Milan, Italy
来源：
MAGNESIUM RESEARCH | 2019年 / 32卷 / 01期
关键词：
magnesium; blood-brain barrier; lipopolysaccharide; SULFATE; DYSFUNCTION; MODULATION; STRESS; CELLS; MODEL;
D O I：
10.1684/mrh.2019.0454
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The blood-brain barrier (BBB) tightly regulates the homeostasis of the central nervous system, and its dysfunction has been described in several neurological disorders. Since magnesium exerts a protective effect in the brain, we assessed whether supraphysiological concentrations of different magnesium salts modulate the permeability and magnesium transport in in vitro models of rat and human BBB. Among various formulations tested, magnesium pidolate was the most efficient in reducing the permeability and in enhancing magnesium transport through the barrier. We then compared magnesium pidolate and magnesium sulfate, a widely used salt in experimental models and in clinical practice. Magnesium pidolate performs better than sulfate also in preventing lipopolysaccharide-induced damage to in vitro generated BBB. We conclude that magnesium pidolate emerges as an interesting alternative to sulfate to protect BBB and maintain correct intracerebral concentrations of magnesium.
引用
收藏
页码：16 / 24
页数：9
相关论文
共 28 条
  • [11] Iotti S, SOURCE MAGNESIUM CEN, P3
  • [12] Real-time in vivo two-photon imaging study reveals decreased cerebro-vascular volume and increased blood-brain barrier permeability in chronically stressed mice
    Lee, Sohee
    Kang, Bok-Man
    Kim, Jae Hwan
    Min, Jiwoong
    Kim, Hyung Seok
    Ryu, Hyunwoo
    Park, Hyejin
    Bae, Sungjun
    Oh, Daehwan
    Choi, Myunghwan
    Suh, Minah
    [J]. SCIENTIFIC REPORTS, 2018, 8
  • [13] Endothelial cells and magnesium: implications in atherosclerosis
    Maier, Jeanette A. M.
    [J]. CLINICAL SCIENCE, 2012, 122 (9-10) : 397 - 407
  • [14] Social stress induces neurovascular pathology promoting depression
    Menard, Caroline
    Pfau, Madeline L.
    Hodes, Georgia E.
    Kana, Veronika
    Wang, Victoria X.
    Bouchard, Sylvain
    Takahashi, Aki
    Flanigan, Meghan E.
    Aleyasin, Hossein
    LeClair, Katherine B.
    Janssen, William G.
    Labonte, Benoit
    Parise, Eric M.
    Lorsch, Zachary S.
    Golden, Sam A.
    Heshmati, Mitra
    Tamminga, Carol
    Turecki, Gustavo
    Campbell, Matthew
    Fayad, Zahi A.
    Tang, Cheuk Ying
    Merad, Miriam
    Russo, Scott J.
    [J]. NATURE NEUROSCIENCE, 2017, 20 (12) : 1752 - +
  • [15] Blood-Brain Barrier Breakdown in the Aging Human Hippocampus
    Montagne, Axel
    Barnes, Samuel R.
    Sweeney, Melanie D.
    Halliday, Matthew R.
    Sagare, Abhay P.
    Zhao, Zhen
    Toga, Arthur W.
    Jacobs, Russell E.
    Liu, Collin Y.
    Amezcua, Lilyana
    Harrington, Michael G.
    Chui, Helena C.
    Law, Meng
    Zlokovic, Berislav V.
    [J]. NEURON, 2015, 85 (02) : 296 - 302
  • [16] Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial
    Pouteau, Etienne
    Kabir-Ahmadi, Marmar
    Noah, Lionel
    Mazur, Andre
    Dye, Louise
    Hellhammer, Juliane
    Pickering, Gisele
    Dubray, Claude
    [J]. PLOS ONE, 2018, 13 (12):
  • [17] Synthesis of a highly Mg2+-selective fluorescent probe and its application to quantifying and imaging total intracellular magnesium
    Sargenti, Azzurra
    Farruggia, Giovanna
    Zaccheroni, Nelsi
    Marraccini, Chiara
    Sgarzi, Massimo
    Cappadone, Concettina
    Malucelli, Emil
    Procopio, Alessandra
    Prodi, Luca
    Lombardo, Marco
    Iotti, Stefano
    [J]. NATURE PROTOCOLS, 2017, 12 (03) : 461 - 471
  • [18] Magnesium deficiency induces anxiety and HPA axis dysregulation: Modulation by therapeutic drug treatment
    Sartori, S. B.
    Whittle, N.
    Hetzenauer, A.
    Singewald, N.
    [J]. NEUROPHARMACOLOGY, 2012, 62 (01) : 304 - 312
  • [19] Cerebrovascular Dysfunction and Blood-Brain Barrier Permeability Induced by Oxidized LDL are Prevented by Apocynin and Magnesium Sulfate in Female Rats
    Schreurs, Malou P. H.
    Cipolla, Marilyn J.
    [J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2014, 63 (01) : 33 - 39
  • [20] Anatomy and physiology of the blood-brain barrier
    Serlin, Yonatan
    Shelef, Ilan
    Knyazer, Boris
    Friedman, Alon
    [J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2015, 38 : 2 - 6
123