Molecular Landscape and Therapeutic Strategies in Cholangiocarcinoma: An Integrated Translational Approach towards Precision Medicine

被引：9

作者：

Casadio, Marco ^{[1
]}

Biancaniello, Francesca ^{[1
]}

Overi, Diletta ^{[2
]}

Venere, Rosanna ^{[1
]}

Carpino, Guido ^{[3
]}

Gaudio, Eugenio ^{[2
]}

Alvaro, Domenico ^{[1
]}

Cardinale, Vincenzo ^{[4
]}

机构：

[1] Univ Roma La Sapienza, Dept Translat & Precis Med, Viale Univ 37, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Dept Anat Histol Forens Med & Orthoped Sci, Via Borelli 50, I-00161 Rome, Italy

[3] Univ Rome Foro Italico, Dept Movement Human & Hlth Sci, Div Hlth Sci, Piazza Lauro Bosis 6, I-00135 Rome, Italy

[4] Sapienza Univ Rome, Med Surg & Biotechnol Sci, Corso Repubbl 79, I-04100 Latina, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 11期

基金：

欧盟地平线“2020”;

关键词：

cholangiocarcinoma; precision medicine; molecular signatures; targeted therapy; BILIARY-TRACT CANCER; PHASE-II TRIAL; OPEN-LABEL; GEMCITABINE; MULTICENTER; OXALIPLATIN; CHEMOTHERAPY; PANITUMUMAB; COMBINATION; SORAFENIB;

D O I：

10.3390/ijms22115613

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cholangiocarcinomas (CCAs) are heterogeneous biliary tract malignancies with dismal prognosis, mainly due to tumor aggressiveness, late diagnosis, and poor response to current therapeutic options. High-throughput technologies have been used as a fundamental tool in unveiling CCA molecular landscape, and several molecular classifications have been proposed, leading to various targeted therapy trials. In this review, we aim to analyze the critical issues concerning the status of precision medicine in CCA, discussing molecular signatures and clusters, related to both anatomical classification and different etiopathogenesis, and the latest therapeutic strategies. Furthermore, we propose an integrated approach comprising the CCA molecular mechanism, pathobiology, clinical and histological findings, and treatment perspectives for the ultimate purpose of improving the methods of patient allocations in clinical trials and the response to personalized therapies.

引用

页数：16

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