Separation of no-carrier-added (NCA) Zr-88 from natural yttrium target irradiated with proton beam has been studied using nature-resourced material, potato peel, which is a commonly available domestic waste. Here, an attempt has been undertaken to exploit natural resource as separating agent. Good separation of NCA Zr-88 from bulk Yttrium target could be achieved at 0.01 M HCl concentration, when extraction was carried out using 20 mg potato peel charcoal-a natural bio-sorbent. Zr-88 was extracted in the solid phase leaving behind bulk Y in the aqueous phase.