Hierarchical computation in the canonical auditory cortical circuit

被引：78

作者：

Atencio, Craig A. ^{[1
,2
,3
]}

Sharpee, Tatyana O. ^{[2
]}

Schreiner, Christoph E. ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Francisco, Univ Calif Berkeley, Bioengn Grad Grp, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, WM Keck Fdn Ctr Integrat Neurosci, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Otolaryngol Head & Neck Surg, Coleman Mem Lab, San Francisco, CA 94143 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2009年 / 106卷 / 51期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

auditory cortex; cortical laminae; information; spectrotemporal receptive field; RECEPTIVE-FIELD; FUNCTIONAL ARCHITECTURE; COLUMNAR ORGANIZATION; RESPONSE PROPERTIES; CORTEX AI; CAT; NEURONS; INFORMATION; LAMINAR; LAYER;

D O I：

10.1073/pnas.0908383106

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sensory cortical anatomy has identified a canonical microcircuit underlying computations between and within layers. This feed-forward circuit processes information serially from granular to supragranular and to infragranular layers. How this substrate correlates with an auditory cortical processing hierarchy is unclear. We recorded simultaneously from all layers in cat primary auditory cortex (AI) and estimated spectrotemporal receptive fields (STRFs) and associated nonlinearities. Spike-triggered averaged STRFs revealed that temporal precision, spectrotemporal separability, and feature selectivity varied with layer according to a hierarchical processing model. STRFs from maximally informative dimension (MID) analysis confirmed hierarchical processing. Of two cooperative MIDs identified for each neuron, the first comprised the majority of stimulus information in granular layers. Second MID contributions and nonlinear cooperativity increased in supragranular and infragranular layers. The AI microcircuit provides a valid template for three independent hierarchical computation principles. Increases in processing complexity, STRF cooperativity, and nonlinearity correlate with the synaptic distance from granular layers.

引用

页码：21894 / 21899

页数：6

共 47 条

[11] RESPONSES OF NEURONS IN AUDITORY CORTEX OF MACAQUE MONKEY TO MONAURAL AND BINAURAL STIMULATION [J].

BRUGGE, JF ;

MERZENICH, MM .

JOURNAL OF NEUROPHYSIOLOGY, 1973, 36 (06) :1138-1158

[12] Excitatory and suppressive receptive field subunits in awake monkey primary visual cortex (V1) [J].

Chen, Xiaodong ;

Han, Feng ;

Poo, Mu-ming ;

Dan, Yang .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (48) :19120-19125

[13] FUNCTIONAL-ORGANIZATION OF SOUND DIRECTION AND SOUND PRESSURE LEVEL IN PRIMARY AUDITORY-CORTEX OF THE CAT [J].

CLAREY, JC ;

BARONE, P ;

IMIG, TJ .

JOURNAL OF NEUROPHYSIOLOGY, 1994, 72 (05) :2383-2405

[14] TRIGGERED CORRELATION [J].

DEBOER, E ;

KUYPER, P .

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1968, BM15 (03) :169-&

[15] Neuronal circuits of the neocortex [J].

Douglas, RJ ;

Martin, KAC .

ANNUAL REVIEW OF NEUROSCIENCE, 2004, 27 :419-451

[16] Nonlinear spectrotemporal sound analysis by neurons in the auditory midbrain [J].

Escabi, MA ;

Schreiner, CE .

JOURNAL OF NEUROSCIENCE, 2002, 22 (10) :4114-4131

[17] The cortical column: a structure without a function [J].

Horton, JC ;

Adams, DL .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2005, 360 (1456) :837-862

[18]

Huang CL, 2000, J COMP NEUROL, V427, P302, DOI 10.1002/1096-9861(20001113)427:2<302::AID-CNE10>3.0.CO

[19]

2-J

[20] RECEPTIVE FIELDS, BINOCULAR INTERACTION AND FUNCTIONAL ARCHITECTURE IN CATS VISUAL CORTEX [J].

HUBEL, DH ;

WIESEL, TN .

JOURNAL OF PHYSIOLOGY-LONDON, 1962, 160 (01) :106-&

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