A Review of Boron Neutron Capture Therapy: Its History and Current Challenges

被引:64
作者
Jin, Will H. [1 ]
Seldon, Crystal [1 ]
Butkus, Michael [1 ]
Sauerwein, Wolfgang [2 ]
Giap, Huan B. [3 ]
机构
[1] Univ Miami Hlth Syst, Sylvester Comprehens Canc Ctr, Jackson Mem Hosp, Dept Radiat Oncol, 1475 NW 12th Ave,Suite 1500, Miami, FL 33136 USA
[2] Univ Klinikum Essen, Deutsch Gesell Bor Neutroneneinfangtherapie DGBNC, Essen, Germany
[3] Dept Radiat Oncol, Nancy N&JC Lewis Canc & Res Pavil, Savannah, GA USA
关键词
BNCT; neutron capture; particle therapy; neutron therapy; boron; GLIOBLASTOMA-MULTIFORME; BRAIN-TUMORS; PHASE-I; PARA-BORONOPHENYLALANINE; RADIATION-DOSIMETRY; SODIUM BOROCAPTATE; TARGET COMPOUND; NECK-CANCER; TRIAL; BNCT;
D O I
10.14338/IJPT-22-00002.1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Mechanism of Action: External beam, whether with photons or particles, remains as the most common type of radiation therapy. The main drawback is that radiation deposits dose in healthy tissue before reaching its target. Boron neutron capture therapy (BNCT) is based on the nuclear capture and fission reactions that occur when B-10 is irradiated with low-energy (0.0025 eV) thermal neutrons. The resulting B-10(n,alpha)Li-7 capture reaction produces high linear energy transfer (LET) alpha particles, helium nuclei (He-4), and recoiling lithium-7 (Li-7) atoms. The short range (5-9 mu m) of the alpha particles limits the destructive effects within the boron-containing cells. In theory, BNCT can selectively destroy malignant cells while sparing adjacent normal tissue at the cellular levels by delivering a single fraction of radiation with high LET particles. History: BNCT has been around for many decades. Early studies were promising for patients with malignant brain tumors, recurrent tumors of the head and neck, and cutaneous melanomas; however, there were certain limitations to its widespread adoption and use. Current Limitations and Prospects: Recently, BNCT re-emerged owing to several developments: (1) small footprint accelerator-based neutron sources; (2) high specificity third-generation boron carriers based on monoclonal antibodies, nanoparticles, among others; and (3) treatment planning software and patient positioning devices that optimize treatment delivery and consistency.
引用
收藏
页码:71 / 82
页数:12
相关论文
共 50 条
[1]  
[Anonymous], BORON NEUTRON CAPTUR
[2]  
ASBURY AK, 1972, J NEUROPATH EXP NEUR, V3, P278
[3]   In Situ Observations of Blistering of a Metal Irradiated with 2-MeV Protons [J].
Badrutdinov, Alexander ;
Bykov, Timophey ;
Gromilov, Sergey ;
Higashi, Yasuo ;
Kasatov, Dmitrii ;
Kolesnikov, Iaroslav ;
Koshkarev, Alexey ;
Makarov, Alexandr ;
Miyazawa, Takuya ;
Shchudlo, Ivan ;
Sokolova, Evgeniia ;
Sugawara, Hirotaka ;
Taskaev, Sergey .
METALS, 2017, 7 (12)
[4]   Boron delivery agents for neutron capture therapy of cancer [J].
Barth, Rolf F. ;
Mi, Peng ;
Yang, Weilian .
CANCER COMMUNICATIONS, 2018, 38 :1-15
[5]  
Cancer Intelligence Care Systems, 2022, CIC 1
[6]   Boron neutron-capture therapy (BNCT) for glioblastoma multiforme (GBM) using the epithermal neutron beam at the Brookhaven National Laboratory [J].
Chadha, M ;
Capala, J ;
Coderre, JA ;
Elowitz, EH ;
Iwai, J ;
Joel, DD ;
Liu, HYB ;
Wielopolski, L ;
Chanana, AD .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1998, 40 (04) :829-834
[7]   The nuclear photoelectric effect [J].
Chadwick, J ;
Goldhaber, M .
PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL AND PHYSICAL SCIENCES, 1935, 151 (A873) :0479-0493
[8]   Boron neutron capture therapy for glioblastoma multiforme: Interim results from the Phase I/II dose-escalation studies [J].
Chanana, AD ;
Capala, J ;
Chadha, M ;
Coderre, JA ;
Diaz, AZ ;
Elowitz, EH ;
Iwai, J ;
Joel, DD ;
Liu, HGB ;
Ma, RM ;
Pendzick, N ;
Peress, NS ;
Shady, MS ;
Slatkin, DN ;
Tyson, GW ;
Wielopolski, L .
NEUROSURGERY, 1999, 44 (06) :1182-1192
[9]   Boron neutron capture therapy for glioblastoma multiforme using p-boronophenylalanine and epithermal neutrons: Trial design and early clinical results [J].
Coderre, JA ;
Elowitz, EH ;
Chadha, M ;
Bergland, R ;
Capala, J ;
Joel, DD ;
Liu, HYB ;
Slatkin, DN ;
Chanana, AD .
JOURNAL OF NEURO-ONCOLOGY, 1997, 33 (1-2) :141-152
[10]  
CODERRE JA, 1990, CANCER RES, V50, P138