Extramedullary hematopoiesis is dysregulated in histamine-free histidine decarboxylase knockout (HDC-/-) mice

被引：5

作者：

Horvath, Zsuzsanna ^{[1
]}

Pallinger, Eva ^{[2
]}

Horvath, Gyozo ^{[3
,4
]}

Jelinek, Ivett ^{[1
]}

Veszely, Gizella ^{[5
]}

Furesz, Jozsef ^{[5
]}

Falus, Andras ^{[1
,2
]}

Buzas, Edit I. ^{[1
]}

机构：

[1] Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary

[2] Semmelweis Univ, Hungarian Acad Sci, Res Grp Inflammat Biol & Immunogenom, H-1089 Budapest, Hungary

[3] Mil Med Ctr, Res Inst, Dept Radiobiol, H-1134 Budapest, Hungary

[4] Frederic Joliot Curie Natl Res Inst Radiobiol & R, Dept Radiat Med & Biodosimetry, H-1221 Budapest, Hungary

[5] State Hlth Ctr, Clin Lab, H-1134 Budapest, Hungary

来源：

INFLAMMATION RESEARCH | 2010年 / 59卷 / 06期

关键词：

Spleen; Histamine; IL-3; signaling; Hematopoiesis; Transgenic mice; GENE-EXPRESSION ANALYSIS; BONE-MARROW; SELF-RENEWAL; STEM-CELLS; G-CSF; PROGENITORS; DIFFERENTIATION; REGENERATION; HOMEOSTASIS; MODULATION;

D O I：

10.1007/s00011-009-0114-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this study we investigated the role of histamine on the extramedullary hematopoiesis. Male histidine decarboxylase knockout (HDC-/-) mice and wild-type mice were used (n = 5/group). Groups of mice received sublethal total-body gamma irradiation at a single dose of 4 Gy. Spleen cells were studied at different time points post-irradiation by flow cytometry, colony forming unit (CFU) assay, and real-time PCR. For statistical analysis Student's t test, ANOVA, and Holm-Sidak post-hoc test were used. By day 14 after irradiation, spleen cell counts increased almost eightfold in wild-type and not even fourfold in HDC-/- mice (P < 0.01). The proliferative capacity and interleukin-3 signaling of stem cells were impaired in HDC-/- mice. STAT5 mRNA expression was decreased in granulocyte-myeloid colonies by 72.9 +/- A 8.6% (P < 0.001), compared to the wild-type. The absence of histamine adversely affects splenic hematopoiesis via direct and indirect mechanisms.

引用

页码：429 / 436

页数：8

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