Novel and highly efficient DNA photocleavers: hydroperoxides of heterocyclic-fused naphthalimides

被引：39

作者：

Yao, W

Qian, XH ^{[1
]}

Hu, QY

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China

[2] E China Univ Sci & Technol, Inst Pesticides & Pharmaceut, Shanghai 200237, Peoples R China

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 40期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0040-4039(00)01304-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel hydroperoxides of heterocyclic-fused naphthalimides were designed, synthesized and exhibited excellent DNA photonicking activities. Among these compounds, the benzothiophenonaphthalimide-type reagent proved to be the most efficient, it can induce single-strand nicks in duplex DNA at micromolar concentration upon illumination. The relationship between the molecular structure and cleaving activities was discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.

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收藏

页码：7711 / 7715

页数：5

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