Neuroprotection of Chrysanthemum indicum Linne against cerebral ischemia/reperfusion injury by anti-inflammatory effect in gerbils

被引：18

作者：

Yoo, Ki-Yeon ^{[1
,2
]}

Kim, In Hye ^{[3
]}

Cho, Jeong-Hwi ^{[3
]}

Ahn, Ji Hyeon ^{[3
]}

Park, Joon Ha ^{[3
]}

Lee, Jae-Chul ^{[3
]}

Tae, Hyun-Jin ^{[4
]}

Kim, Dae Won ^{[2
,5
]}

Kim, Jong-Dai ^{[6
]}

Hong, Seongkweon ^{[7
]}

Won, Moo-Ho ^{[3
]}

Kang, Il Jun ^{[8
]}

机构：

[1] Gangneung Wonju Natl Univ, Coll Dent, Dept Oral Anat, Kangnung, South Korea

[2] Gangneung Wonju Natl Univ, Res Inst Oral Sci, Kangnung, South Korea

[3] Kangwon Natl Univ, Dept Neurobiol, Sch Med, Chunchon, South Korea

[4] Hallym Univ, Res Inst Biosci & Biotechnol, Dept Biomed Sci, Chunchon, South Korea

[5] Gangneung Wonju Natl Univ, Coll Dent, Dept Biochem & Mol Biol, Kangnung, South Korea

[6] Kangwon Natl Univ, Sch Biotechnol, Div Food Biotechnol, Chunchon, South Korea

[7] Kangwon Natl Univ, Sch Med, Dept Surg, Chunchon, South Korea

[8] Hallym Univ, Dept Food Sci & Nutr, Chunchon, South Korea

来源：

NEURAL REGENERATION RESEARCH | 2016年 / 11卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

nerve regeneration; transient cerebral ischemia; delayed neuronal death; pyramidal neurons; inflammatory cytokines; neural regeneration; HIPPOCAMPAL CA1 REGION; TRANSIENT FOREBRAIN ISCHEMIA; DELAYED NEURONAL DEATH; FLUORO-JADE B; REPERFUSION INJURY; INFLAMMATORY CYTOKINES; TEMPORAL PROFILE; ARTERY OCCLUSION; RAT HIPPOCAMPUS; TANSHINONE IIA;

D O I：

10.4103/1673-5374.177735

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this study, we tried to verify the neuroprotective effect of Chrysanthemum indicum Linne (CIL) extract, which has been used as a botanical drug in East Asia, against ischemic damage and to explore the underlying mechanism involving the anti-inflammatory approach. A gerbil was given CIL extract for 7 consecutive days followed by bilateral carotid artery occlusion to make a cerebral ischemia/reperfusion model. Then, we found that CIL extracts protected pyramidal neurons in the hippocampal CA1 region (CA1) from ischemic damage using neuronal nucleus immunohistochemistry and Fluoro-Jade B histofluorescence. Accordingly, interleukin-13 immunoreactivities in the CA1 pyramidal neurons of CIL-pretreated animals were maintained or increased after cerebral ischemia/reperfusion. These findings indicate that the pre-treatment of CIL can attenuate neuronal damage/death in the brain after cerebral ischemia/reperfusion via an anti-inflammatory approach.

引用

页码：270 / 277

页数：8

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