Hypofractionation should be the new 'standard' for radiation therapy after breast conserving surgery

被引:45
作者
Holloway, Caroline L.
Panet-Raymond, Valerie
Olivotto, Ivo [1 ]
机构
[1] BC Canc Agcy, Vancouver Isl Ctr, Victoria, BC V8R 6V5, Canada
关键词
Breast cancer; Radiation therapy; Fractionation; RANDOMIZED CLINICAL-TRIAL; COMPARING TOTAL MASTECTOMY; 20-YEAR FOLLOW-UP; POSTOPERATIVE RADIOTHERAPY; CONSERVATIVE SURGERY; PREMENOPAUSAL WOMEN; AXILLARY DISSECTION; RADICAL-MASTECTOMY; UK STANDARDIZATION; CANCER PATIENTS;
D O I
10.1016/j.breast.2010.03.002
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hypofractionated whole breast radiation therapy following breast conserving surgery (BCS) has been used in many institutions for several decades. Four randomized trials with 5-10-year follow-up, have demonstrated equivalent local control, cosmetic and normal tissue outcomes between 50 Gy in 25 fractions and various hypofractionated RT prescriptions employing 13-16 fractions. Indirect evidence suggests that hypofractionated RT may also be safe and effective for regional nodal RT. In the face of equivalent outcomes, patient convenience and health care utilization benefits, hypofractionated RT should be the new 'standard' following BCS. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:163 / 167
页数:5
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