Family History, Mammographic Density, and Risk of Breast Cancer

被引:78
作者
Martin, Lisa J. [1 ]
Melnichouk, Olga [1 ]
Guo, Helen [1 ]
Chiarelli, Anna M. [2 ]
Hislop, T. Gregory [4 ]
Yaffe, Martin J. [3 ]
Minkin, Salomon [1 ]
Hopper, John L. [5 ]
Boyd, Norman F. [1 ]
机构
[1] Ontario Canc Inst, Campbell Family Inst Breast Canc Res, Toronto, ON M5G 2M9, Canada
[2] Canc Care Ontario, Populat Studies & Surveillance, Toronto, ON, Canada
[3] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada
[4] BC Canc Agcy, Vancouver, BC, Canada
[5] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic 3010, Australia
关键词
IGF-BINDING PROTEIN-3; PARENCHYMAL PATTERNS; DEATH RATES; END-POINTS; WOMEN; FEATURES; MODEL; SUSCEPTIBILITY; ASSOCIATION; VALIDATION;
D O I
10.1158/1055-9965.EPI-09-0881
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: Mammographic density is a strong and highly heritable risk factor for breast cancer. The purpose of this study was to examine the extent to which mammographic density explains the association of family history of breast cancer with risk of the disease. Subjects and Methods: We carried out three nested case-control studies in screening programs that included in total 2,322 subjects (1,164 cases and 1,158 controls). We estimated the independent and combined associations of family history and percent mammographic density at baseline with subsequent breast cancer risk. Results: After adjustment for age and other risk factors, compared with women with no affected first-degree relatives, percent mammographic density was 3.1% greater for women with one affected first-degree relative, and 7.0% greater for women with two or more affected relatives (P = 0.001 for linear trend across family history categories). The odds ratios for breast cancer risk were 1.37 [95% confidence interval (95% CI), 1.10-1.72] for having one affected relative, and 2.45 (95% CI, 1.30-4.62) for having two or more affected relatives (P for trend = 0.0002). Adjustment for percent mammographic density reduced these odds ratios by 16% and 14%, respectively. Percent mammographic density explained 14% (95% CI, 4-39%) of the association of family history (at least one affected first-degree relative) with breast cancer risk. Conclusions: Percent mammographic density has features of an intermediate marker for breast cancer, and some of the genes that explain variation in percent mammographic density might be associated with familial risk of breast cancer. Cancer Epidemiol Biomarkers Prev; 19(2); 456-63. (c) 2010 AACR.
引用
收藏
页码:456 / 463
页数:8
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